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17 Cards in this Set
- Front
- Back
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______________________ is a hereditary progressive neurodegenerative disorder of the basal ganglia.
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-HUNTINGTONS DISEASE DUH
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When does HD typically occur?
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midlife, 30-50
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HD occurs as a result of mutation to chromosome ____?
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-4
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The mutation to chromosome 4 results in what?
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Excessive multiplication of a nucleotide triplet (36-125x)
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an individual with > ____ CAG repeats WILL have huntingtons?
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-40
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T or F:
There is a direct correlation between a higher number of CAG repeats and early onset of symptoms? |
-TRUE
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T or F:
each child of a parent with HD will develop the disease? |
-FALSE
-50-50 chance |
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In early HD, is there an increase or decrease in unwanted movements?
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INCREASE:
the D2 (indirect) pathway is stopped. This causes decreased inhibition, thus allowing more unwanted movements to occur. |
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As the disease progresses, what happens to the striatum?
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-In later stages of HD, all striatal projection neurons degenerate, as well as cortical neurons, resulting in a relatively hypokinetic state.
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___________: activation of a programmed cell death pathway.
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-Apoptosis
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Why do some individuals choose to not receive the Gene test?
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This allows them to know whats to come, and as of now there is no way to change the outcome
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T or F:
A stage 1 TFC is worse off then a stage 5 TFC?? |
-FALSE
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Describe 2 signs of premanifested HD.
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-mild gait changes
-Irritability |
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What are two signs a patient with HD has moved into late stage?
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-Global dementia
-Delirium |
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T or F:
Voluntary movement continues to worsen throughout the lifespan of a patient with HD? |
-TRUE
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What is the typical survival rate of HD?
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-15-25 years
Pneumonia and cardiovascular disease are the most common primary causes of death. |
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What is the Mechanism of action for HD medications?
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-OPPOSITE OF PARKINSONS
-BLOCK DOPAMINE |
