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8 Cards in this Set
- Front
- Back
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Primary Neurulation Defects
Anencephaly |
Defect-failure of closure of majority of the rostral neural tube, complete arrest of brain development. neural plate is open, and posterior mesodermal elements are absent
Medical Problems-incompatable with life |
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Primary Neurulation Defects
Myelomeningocele |
Defect-spina bifida, neural plate does not close, focal area on external part of the lower back, failure to close the dorsal spine. apreta, open lesion, occulta defects covered with skin
Medical Problems-skin dimples, lipomas, hairy patches, hemangiomas, appendages |
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Primary Dysjunction
Dermal Sinue Tracts |
Defect-separation of neural tube for overlying ectoderm.
Medical Problems-tracts in skin to spinal canal, anomalies to normal area |
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Premature Dysjunction
Spinal Cord Lipomas |
Defect-unknown cuase. early separation of neural tube for overlying ectoderm, entry of mesenchymal tissue into neural tube, ectoderm closes.
Medical Problems-skin is normal, large lipomas extend from subcut tissues to spinal cord. |
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Secondary Neurulation Defects
Lipoma of Filum Terminale |
Defect-Failure of regression of filum leads to fat formation, leading to lipomas of the filum.
Medical Problems-signs and symptoms of lower extermity, bowel and bladder. |
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Secondary Neurulation Defects
Myelocystocele |
severe form of terminal filum lipoma, with cystic dilation of teh conus medullaris.
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Post Neurulation Defects
Encephalocele |
central nervous system structures hernites throug defect in calavarium.
occur in areas of mesenchymal disruption |
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Myelomeningocele
epi and treatment |
teratogen casued. lower extremity dysfunction (depending at level), bowel and bladder incontinenece, hydrocephalus, hindbrain abnormalities, orthopedic abnormailties.
1/2000 live births, (folic acid sup helps) experimental evidence is limited tx 1. prevent infection 2. continous layer of skin over lesion, decompressing CSF closing the dura, and closing the skin, shunt catheter, drains CSF fetal surgery |
