Human Function Test 1 Drugs And Poisons

Front 1

Losartan

Back 1

Treat: Marfan Syndrome

decreases the expression of TGF beta

Front 2

Beta- Blockers

Back 2

Treat: Marfan Syndrome, Heart Disease

Block Beta adrenorgic receptors. Decrease heart rate

Front 3

Organophosphate (DFP)

Back 3

TOXIN

Irreversibly binds to AChE - inhibiting ACh breakdown

Front 4

Atropine

Back 4

Treat: Anti-toxin (organophosphate) and Heart Rate modulator

Competitive inhibitor of ACh receptors.
Decreases EPP; increases rate of SA node

Front 5

Pralidoxime

Back 5

Treat: Anti-toxin (organophosphate)

Binds w/ organophosphate, removing it from the active site of AChE

Front 6

Pyridostigmine Bromide

Back 6

Treat: Myasthenia Gravis

Reversibly inhibits AChE, increases EPP

Front 7

Aspirin

Back 7

Non-Steroidal Anti-inflamitory Drug
Treat: Pain, inflammation, and inhibit clotting

irreversibly inhibits COX (cyclooxygenase) which is responsible for thromboxane and prostoglandin formation

Front 8

Ibuprofen

Back 8

Non-Steroidal Anti-inflamitory Drug
Treat: Pain, inflammation, and inhibit clotting

reversibly inhibits COX (cyclooxygenase) which is responsible for thromboxane and prostoglandin formation

Front 9

Invirase, Crixivan, Viracept, Norvir
(HIV Protease Inhibitors)

Back 9

Treat: HIV/AIDS

All are transition state analogs (tetrahedral), -OH reversibly binds to active site of HIV Protease

Front 10

Penicillin

Back 10

Treat: bacterial infections

Suicide inhibit of cell wall transpeptidase. Prevents formation of stable wall --> cells prone to lysing. beta-lactam ring opens up during reaction w/ transpeptidase resulting in a fast, strong, favorable reaction.

Front 11

Tetrodotoxin (TTX)

Back 11

TOXIN

Blocks Fast Na+ Channels, preventing normal depolarization

Front 12

Clavulanic Acid

Back 12

Treat: penicillin-resistant bacterial infections

Inactivates bacterial beta-lactamase, allowing penicillin (or penicillin analogs) to function

Front 13

Augmentin

Back 13

Treat: penicillin resistant bacteria

Drug cocktail containing Amoxicillin (penicillin analog) & Clavulanic Acid

Front 14

Class 1 Anti-arrhythmics

Back 14

Treat: arrhythmia

Block Na channels in damaged cardiac cells to prevent random depolarizations

Front 15

Warfarin (Coumadin), Dicoumarol

Back 15

Treat: prevent excessive clotting

Competitvely inhibit Vitamin K Reductase, preventing the recylcing of Vit K and the addition of gla residues to clotting factors

Front 16

Heparin

Back 16

Treat: excessive clotting

Promotes Antithrombin 3, a serpin which inactivates Thrombin

Front 17

Tissue Plasminogin Activator (TPA)

Back 17

Treat: excessive clotting

Activates plasminogen to plasmin leading to fibrin proteolysis

Front 18

Hemicholinium

Back 18

TOXIN

Blocks choline transporter at nerve terminals, lowering ACh synthesis

Front 19

Cyanide

Back 19

TOXIN

Blocks Mitochondrial functions including Acetyl-CoA synthesis

Front 20

Botulinum Toxin

Back 20

TOXIN
Treats: wrinkles

Irreversibly binds to presynaptic terminal, prevents the release of ACh

Front 21

Colchicines

Back 21

TOXIN

Breaks orientation of microtubules, inhibits vesicle release

Front 22

Curare

Back 22

TOXIN
(Monkey Hunter!)

Inhibits ACH receptor binding -- reversible

Front 23

Succinylcholine

Back 23

TOXIN

Binds to ACh receptors, opening channels binding

Front 24

alpha-bungarotoxin

Back 24

TOXIN

Binds irreversibly to ACh receptor

Front 25

Edrophonium

Back 25

Treat: Myasthenia Gravis diagnosis

Prevents hydrolysis of ACh, enhances EPP