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30 Cards in this Set
- Front
- Back
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The larynx is _________ to the thyroid gland
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superior
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Follicle cells produce the glycoprotein _________
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thyroglobulin
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The cavity of the follicle stores ____ consisting of thyroglobulin molecules with attached iodine atoms
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colloid
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Thyroid hormone is derived from this _____________
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iodinated thyroglobulin
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The ___________ cells produce calcitonin. These cells lies surrounding the thyroid follicle
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parafollicular cells
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(T3/T4) is produced at 10x greater than (T3/T4)
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T4
T3 |
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(T3/T4) is 4x more potent than (T3/T4)
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T3
T4 |
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(T3/T4) is secreted in plasma eventually converted by liver, kidney or target tissue to more active (T3/T4)
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T4
T3 |
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Where are thyroglobulin synthesized?
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In the ribosomes
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Iodine moves into the follicle lumen by?
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Facilitated diffusion
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Iodines are ________ to iodine at the border of the follicle cells and colloid
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oxidized
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Iodine is attached to tyrosine amino acids which occurs at the junction of the ......
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follicle cell apex
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The attachment of the iodine to tyrosine amino acids is mediated by....
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peroxidase enzyme
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Attachment of 1 iodine to a tyrosine produces .........
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Monoiodotyrosine
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Attachment of 2 iodine to a tyrosine produces
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diiodotyrosine
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DIT + DIT =
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T4
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MIT + DIT =
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T3
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T4 and T3 immediately binds to transport proteins known as ____________ produced by the liver
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thyroxine-binding globulin
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What is the 2 main factor that causes a release in TRH from the hypothalamus?
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Stress and cold temperature (infant)
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TRH targets which organ to cause an increase in TSH secretion?
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Anterior pituitary
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Factors that inhibit TSH release are
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GHIH
Dopamine An increase in glucocoticoid |
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The c cells of the thyroid gland is located ....
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between follicle cells and basement membrane
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C cells of parathyroid glands produce the hormone
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calcitonin
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What is the function of calcitonin
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Aids the regulation of Ca2+ concentration in body fluids
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The 2 disease associated with hypothyroidism is called
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Hashimotos thyroiditis
Myxoedema |
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An overdose to the treatment of hypothyroidism can lead to
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Angina
Cardiac dysrhythmia Hyperthyroidism |
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What is the disease associated with hyperthyroidism
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Graves' disease
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Another disorder of the thyroid gland is
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the grave's optithalmopathy
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Give 2 example of anti-thyroid drugs
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Carbamizole
Propylthiouracil |
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B blocker such as ____________ can be used as a treatment of hyperthyroidism
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propanolol
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