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33 Cards in this Set
- Front
- Back
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Which component of the cell membrane is key to Selective Permeability? |
Protein Component |
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Name 4 types of membrane proteins |
1. Channel 2. Transporters 3. Receptors 4. Enzymes 5. Connexins |
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What do Channel Proteins move? |
ions and other really small molecules |
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What do transporters move? |
Amino Acids/ Drugs/ Sugars |
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What do receptors bind to? |
Ligands |
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What does the CFTR channel stand for? |
Cystic Fibrosis Transporter Regulator |
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What is another name for the Drug Efflux Pump? |
Transporter ABCB1 |
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What does the Drug Efflux Pump cause? |
Multi-drug Resistance |
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What does mutations in connexin 26 cause? |
Deafness |
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In which cells is Connexin 26 found in? |
Cochlear Cells |
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What do Membrane Channel Proteins mediate? |
the PASSIVE movement of solutes |
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in the middle of an un-stimulated channel protein what is found? |
a charged side chain of AMINO ACIDS |
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How is a channel protein stimulated? (2 answers) |
1. change in voltage in cell membrane 2. a ligand binding to the channel protein |
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do passive transporters have a ligand on only one side of the cell membrane? |
YES |
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by which kind of diffusion do molecules move through a passive transporter? |
facilitated diffusion |
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what causes a passive transporter to undergo conformational change? |
the binding of a LIGAND |
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in a passive transporter, what is the Net Flux dependent on? |
the electrochemical and the concentration gradients |
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in active transporters, is the first binding site high or low affinity? |
High affinity |
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In active transporters, what does solute binding induce? |
the binding and the lysis of ATP |
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What kind of pump is an active transporter? |
Primary Active Pump |
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In an active transporter, what is net flux dependent on? |
ATP |
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What kind of chemical does COUPLED TRANSPORT require? |
an ion |
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In Coupled Transport, what is released as the co-transported ion moves down its electrochemical gradient? |
Free Energy |
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In coupled transport, what kind of active transport is being displayed? |
Secondary Active Transport |
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Give an example of a Primary Active Transporter |
ABCB1 - Drugs Efflux Transporter |
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Referring to coupled transport, if 2 substrates are entering a cell via a transporter, what is the term used? |
Symport |
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Give an example of a Secondary active transporter |
Sodium/Glucose linked transporter (INTESTINAL EPITHELIUM) |
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How does receptor mediated endocytosis occur? |
1. A receptor protein has its substrate bind to its binding site 2. this causes a CONFORMATIONAL change in the receptor protein 3. Conformational change causes CLATHRIN to bind to receptor proteins 4. Clathrin-coated pit turns cell membrane (containing substrates) into a vesicle |
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where is the CFTR channel found? |
Epithelial cells of: 1. Lungs 2. Intestine 3. Pancreas |
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What kind of ion flows through the CFTR channel? |
Chlorine ion (Cl-) |
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In a person who does not suffer from Cystic Fibrosis, what does the ejection of Cl- from an epithelial cell induce? |
The ejection of Na+ and water from the epithelial cell (PARACELLULARLY) |
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What would mutant CFTR channels cause and why? |
Chronic infection, due to viscous mucous, due to water not being induced to leave cell |
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What kind of mutation is Cystic Fibrosis? |
Autosomal Recessive |
