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22 Cards in this Set
- Front
- Back
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Zanaminvir |
-competitive inhibitors of NA (neuraminidase)q -sialic acid analogues - treat A&B -virus gets stuck in cell and cannot spread |
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What is a common side effect of Zanamivir |
bronchospasm due to inhalation |
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Oseltamivir |
-competitive inhibitor of NA (neuraminidase) - virus cannot leave cell -treats A&B -oral |
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What are the side effects of ostelamivir? |
neuropsychiatric events |
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Amantidine |
-treat only type A influenza -develop resistance to M2 inhibitor--> prvenet virion pH change--> prevents uncoating go virus MrRNA |
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What are the common side effects of amantidine? |
neurotoxicity in elderly |
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Rimantidine |
-treats only influenza type A -development of resistance to M2 inhibitors -prevent uncoating of viral MRNA
use for old people no psycho events
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Palivizumab |
-use in premature babies for RSV -inhibits viral entry into cells
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What is a negative about Palivizumab |
most insurance companies will not cover it because it is mucho $$$$$$$
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Steroids or bronchodilators |
potential to decrease but no proven benefir discontinue if no immediate relief |
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Ribavarin |
- mechanism is unclear but it may be a nucleoside analog
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What are the side effects of Ribovarin |
oral dose-toxic and tetragenic toxic to those around have to make an aerosol tent |
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What is the MOA of beta lactam antibiotics? |
inhibit transpeptidation blocking crosslinking of peptidoglycan chain
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MRSA resistance |
make new PBP binding protein |
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What is the MOA of vancomycin |
binds AL AL and inhibits transglycosylase |
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What is the side effect of vancomycin? |
ototoxicity nephrotoxicity |
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what is the MOA of clindamycin |
protein synthesis inhibitor |
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What is the most common adverse rxn to clindamycin |
diahreaa |
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What is the empirical treatment for epiglotitis |
3rd generation beta lactam and vancomycin |
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What are the 3rd generation cephalosporins called |
ceftriaxone cefotaxamine ceftazimide cefdinir |
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If someone is allergic to beta lactam antibiotics and had epiglotitis what would you give them? |
levofloxacin (flouroquinolone)
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What is the MOA of levoflaxin |
DNA transcription and translation inhibited |
