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31 Cards in this Set
- Front
- Back
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What is the source of TNF?
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macrophage
Th1 cell |
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What are the targets of TNF?
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Endothelial cells
Neutrophils Hypothalamus Liver Muscle/fat |
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What is TNF's effect on the endothelial cells?
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Activation of vascular endothelium-->increased adhesion molecules for macrophage attachment to exit blood & enter infection site-->increase permeability
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What is TNF's effect on neutrophils?
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Activation of neutrophil's microbicidal activity
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What is the source of IL-1?
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Macrophage
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What are the targets of IL-1?
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endothelial cells
hypothalamus liver |
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What effect does IL-1 have on its target cells?
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endothelial cells: activation
hypothalamus: fever liver: synthesis of acute-phase proteins |
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What is the source of IL-12?
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macrophage and dendritic cells
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What are p35 and p40?
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IL-12
cytokines |
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What are the target cells of IL-12?
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naive CD4+ T cells
NK cells & T cells |
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What is the effect of IL-12 on naive CD4+ T cells?
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Th1 differentiation
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What is the effect of IL-12 on T cells and NK cells?
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IFN-gamma synthesis
Increased cytolytic activity |
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What are the type I IFNs?
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IFN-alpha
IFN-beta |
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What are the target cells of IFN-alpha?
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All cells
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What are the target cells of IFN-beta?
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NK cells
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What is the effect of IFN-alpha on its target cells?
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induce antiviral state
Increase MHC class I synthesis |
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What is the effect of IFN-beta on its target cells?
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Activate
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Where is IL-6 made?
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macrophage
endothelium T cell |
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What are the targets of IL-6?
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Liver, B cells
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What is the effect of IL-6 on B cells?
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Proliferation
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What are the targets of IL-6?
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Liver
B celsl |
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What is the effect of IL-6 on the liver?
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Syhntehsis of actue phase proteins
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What is the source of IL-10?
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macrophages
activated Th2 cells |
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What is the target of IL-10?
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macrophages
dendritic cells |
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What is the effect of IL-10 on its targets?
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Inhibition of IL-12 production
Inhibition of the expression of costimulatory B7 molecuels and MHC calss II |
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What is the source of IL-2?
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Activated CD4 T cells
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What is the target of IL-2?
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Th1 and Th2 cells
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What is the effect of IL-2 on its targets?
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T cell proliferation
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What is the source of TGF-beta?
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Activated Th2 cells
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What is the target of TGF-beta?
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Th1 cells
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What is the effect of TGF-beta on its target cells?
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Inhibtion of Th1 cell proliferation
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