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17 Cards in this Set
- Front
- Back
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Hyp/pit axis feedback
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ultimate homones send negative feedback to hypothalamus and anterior pituitary
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Hypothalamus releasing hormones
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TRH (to release TSH), GnRH (to release LH and FSH), GRH(to release GH/somatostatin), GIH(inhibit somatostatin release), CRH (stimulated by angiotensin II, to release ACTH), PRF (prolactin), PIF(inhibit lactotrope release of prolactin)
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GH
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growth hormone, anterior pit, long bone growth
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FSH
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Follicle stimulating hormone, acts on Sertoli cells of seminiferous tubule--> increase proteins in sperm; in ovarian follicles--> maturation of ovum and production of estradiol
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TSH
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Thyrotropin, go to follicle cells of thyroid gland, release T4 and T3
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ACTH
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to adrenal cortex-->make corticosteroids
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LH
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Lutinizing hormone, Leydig cells of testes--> up testosterone syn and release; and on corpus luteum of ovarys--> up progesterone production and release
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Prolactin
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milk production in mammary glands
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Beta-endorphin
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acts on cells and neurons to produce analgestic effects (binds to opiate receptors)
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MSH
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melanocyte-stimulating hormone, skin cells for dispersion of melanin (skin darkening)
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Oxytocin
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From posterior pituitary, uterine contractions and mild letdown
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ADH
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posterior pituitary to kidneys--> water retention
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control of GH secretion
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release in anterior pit from stimulation by GRH- growth hormone releasing hormone and somatostatin (GIH)
(IGF-1 is what works on periphery) |
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GH secretion stimulators
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hypoglycemia, stress, ghrelin (releasing factor from GI), Amino acids
[dose dependent DECREASE in fat and INCREASE in muscle and bone] |
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GI secretion inhibitors
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glucose, IGF-1(insulin like growth factor), free fatty acids
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Laron dwarfism
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GH deficiency/inactivity b/c mutation in gene or GH binding protein gene
Tx: with synthetic GH |
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Acromegaly
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hypersomatropism- too much GH; bigger jaw, finger, tufting and calcification in terminal phalanges
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