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5 Cards in this Set
- Front
- Back
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What determines male phenotype?
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SRY gene on short arm of Y chromosome
SRY ---> Testes Determining Factor (TDF) Testes (sertoli cells --MIH--> leydig cells)--> testosterone, androstenedione --> male differentiation |
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What determines female phenotype?
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Two X chromosomes
Females with only one X chromosome usually have "streaked" ovaries |
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Hormones released by Leydig cells and effects
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Testosterone, Adrostenedione
induction of these hormones and ability to respond determines masculine differentiation of mesonephric ducts and external genitalia |
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Hormones released by Sertoli cells and effects
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Antimullerian Hormone: suppresses development of mullerian (paramesonephric) ducts
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Testosterone's role in testes development
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needed for normal movement of testes at 26 weeks --> inguinal canal --> scrotum
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