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15 Cards in this Set

  • Front
  • Back
Hidrosoluble Hormones
Membrane Receptor
Insuline
Glucagon
Catecolamies
ADH
Lipid Soluble Hormones
Intracelular Receptor
Steroids
Thyroxine
Calcicitriol
Retinoic acid
What are Protein Kinases?
enzymes that phosphorilates many other proteins, changing their activity.
Protein Kinase A,C,G, and Thyrosine Kinase
The four Pathways for water soluble Hormones?
cAMP
PIP2
cGMP
insuline and growth factors
What are protein phosphatases?
enzymes that Dephosphorilates, many other proteins changing their activity
What are receptor in these pathways coupled through?
trimeric G proteins
(membrane Receptors)
Subunits of trimeric G proteins?
alpha
beta
gamma
What happens to the G protein when the hormone binds the membrane receptor?
Receptor becomes activated and engages the corresponding G protein,
alpha binds GTP, so alpha dissociates from beta and gamma,
The activated alpha subunits alters the activity of Adenylcyclase
G proteins in inactive form?
alpha subunit binds to GDP, and is in complex with beta and gamma.
Is alpha subunit is a s?
adenylcyclase is activated
if alpha is 1?
adenylcyclase is ihibited?
So How is the trimeric G protein cycle completed
after the above steps, the activated GTP, is dephosphorilated in GDP, and alpha will rebind to beta, and gamma, therefore inactive again
Hormones that use the cAMP pathway?
Glucagon, epinefrin (beta,alpha2),norepinefrin
Sequence for this pathway?
Hormone binds receptor,
Trimeric G protein engaged ( Gs,Gi)
Adenylcyclase function altered
cAMP concentration altered (Second messenger)
Protein Kinase A
Phosphorilation of proteins(enzymes, CREB proteins,etc)
The epinephrine and the beta 1 receptor sequence?
epi binds to receptor in cell membrane,
receptor engages trimeric Gs protein,
activated adenylcyclase
increases cAMP concentration,
activates protein kinase A,
Phosphorilation of ligand gated Calcium chanel,
chanel opens,
calcium inside cardiac musle cell increases,
interaction between actin and miosin increases,
contractilily increases.