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12 Cards in this Set
- Front
- Back
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what is the difference between primary and secondary blood homeostasis?
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primary is platelet plug formation and secondary is clotting cascade
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What are the roles of von willebrand factor?
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necessary for platelet adhesion in high shear stress areas AND stabilizes (keeps inactive) factor VIII
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What are citrate and oxalate and how do they work?
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Ca binders prevent coagulation (which needs Ca)
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Normal PT time?
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11-14 seconds
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Normal APTT time?
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25-38 seconds
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What does factor XIII do?
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Stabilized fibrin clots
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Which clotting factors are Vit K dependent?
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II, VII, IX, X (proteins C and S)
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What does a prolonged thrombin time mean?
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either a fibrinogen deficiency or presence of thrombin inhibitors (like heparin)
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Why don't you start bleeding patients on coumadin?
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b/c it takes 3-5 days to deplete stores of fxnl clotting factors
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What do proteins C and S do?
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Inhibit factors V and VIII
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what does plasminogen do?
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Chews up fibrin clots
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Lab values in DIC?
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prolonged PT and PTT, elevated D-Dimer, schistocytes…thrombocytopenia, fibrinogenemia, low factor 5
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