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11 Cards in this Set
- Front
- Back
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What is the name of the staging system used and what are the criteria for the staging systems?
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Ann Arbor
A and B symptoms - B = night sweats, fever (>38), weight loss (>10% of body mass in 6months) |
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Which is more common, Hodgkin or non Hodgkin?
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non-hodgkin is 9-10times more common than hodgkin lymphoma
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what is the typical presentation of hodgkin lymphoma
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upper torso lymphadenopathy
mediastinal mass on CXR B-symptoms - proportional to volume of tumor and due to cytokines release by tumor cells |
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Why is an excisional biopsy performed for diagnosis of hodgkin lymphoma and not an FNA or core biopsy?
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malignant cells make up less than 1% of tumor mass, majority of cells are immune reactive stromal and inflammatory cells.
thus false negative from FNA/ cor biopsy is high |
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How is hodgkin lymphoma treated?
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radiotherapy +/- chemotherapy
radiotherapy i used to target bulky sites. If disease is disseminated chemotherapy is required. |
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what are some prognostic markers of hodgkin lymphoma?
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serum albumin, Hb, gender, Stage, Total WCC >15, lymphocytes, age >45
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what is the standard chemotherapy regime for tx of hodgkin lymphoma
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ABVD
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what chemotherpy regimen is used to treat advanced stage non-hodking lymphoma?
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BEACOPP
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what are the long term complications of Tx of hodgkin lymphoma
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AML
Non-hodgkin lymphoma pts who received RTx -> breast, thyroid, lung, bone, GI and brain Ca |
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what is the typical finding on lymph node biopsy suggestive of hodgkin lymphoma?
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Reed-Sternberg cell - large cell with two nuclei with prominent nucleoli
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what is the translocation in follicular non-hodgkin lymphoma and what does this cause?
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t(14;18)
results in bcl-2 -> impaired apoptosis |
