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15 Cards in this Set
- Front
- Back
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At what age does HL most commonly occur
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bimodal peak. age 25 and age 60-70 yrs.
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What are 2 broad histologic categories of HL? which is more common?
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1. Classic (more common)
2. Nodular lymphocyte predominant HL (NLPHL) |
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What are the subtypes of classic HD and which is most common in the US?
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Subtypes of classic HL:
1. nodular sclerosing (most common in US) 2. mixed cellularity 3. lymphocyte depleted 4. lymphocyte rich (very very rare) |
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What are the 2 most commonly involved LN regions at the initial Dx of HD?
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Most commonly involved LN regions at initial Dx of HL:
1. cervical chains (70% of patients) 2. mediastinum (50% of patients) |
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Pts who present with mediastinal LAD are most likely to have which subtype of HD?
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Pts who present with mediastinal LAD are most likely to have nodular sclerosing HD.
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In classic HL, what is the most common CD15, -30, -45, and-20 staining pattern?
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CD 15 and CD 30 positive
CD 45 and CD 20 negative |
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In NLPHL, what is the most common CD15, -30, -45, and-20 staining pattern?
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CD 15 and CD 30 negative
CD 45 and CD 20 positive |
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What HL subtype has the best prognosis?
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lymphocyte-rich (this is the one that's very rare)
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What HL subtype has the worst prognosis?
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lymphocyte-depleted
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Which HL subtype is associated with older age or HIV+ patients?
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lymphocyte-depleted
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Pts with which subtype of HL are at greatest risk of developing a subsequent non-hodgkin lymphoma?
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NLPHL
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what are the B symptoms?
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1. fevers >38 degrees
2. weight loss, >10% in 6 months 3. drenching night sweats |
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how is bulky mediastinal disease commonly defined?
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mass greater than 1/3 of intrathoracic diameter on T5-T6 on upright PA film
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how is bulky disease defined outside the mediastinum?
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variably defined in clinical trials but most often is either
- any mass > 5cm OR - any mass > 10cm |
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what are the B symptoms?
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1. fevers >38 degrees
2. weight loss, >10% in 6 months 3. drenching night sweats |
