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7 Cards in this Set

  • Front
  • Back
What is purpose of HMP shunt?
1) produce NADPH
2) produce ribulose 5 phosphate for nucleotide synthesis (pentose phosphate pathway)
1)Where does oxidation occur in HMP shunt?
2)What does it produce?
3)In what 2 forms is it shunted back in in the case that nucleotide doesn't occur?
1)Glucose-6-phosphate oxydation via G6Dehydrogenase
3)Fructose-6-phosphate & Glyceraldehyde-3-phosphate
Importance of NADPH in Liver
Drug metabolism
- cytocrome p450
- induce/inhibit drug met
Importance of NADPH in Neutrophils
NADPH oxidase used to kill bacteria
Importance of NADPH in Erythrocyte
RBCs have increased O2 therefore ROS are a problem. If accumulates we can get hgb denaturation (heinz bodies) & membrane damage (hemolytic anemia)
Glutathione redox cycle
Glutathione reductase regenerates reduced glutathione. Glutathione peroxidase reduces H2O2 to water.
When will we often see signs of glucose-6-phosphate dehydrogenase deficiencey?

What is the result?
In oxidative stress
-fava beans
-certain drugs

Heinz bodies & Hemolysis