Hmp Shunt- Biochemistry

Front 1

What is purpose of HMP shunt?

Back 1

1) produce NADPH
2) produce ribulose 5 phosphate for nucleotide synthesis (pentose phosphate pathway)

Front 2

1)Where does oxidation occur in HMP shunt?
2)What does it produce?
3)In what 2 forms is it shunted back in in the case that nucleotide doesn't occur?

Back 2

1)Glucose-6-phosphate oxydation via G6Dehydrogenase
2)NADPH
3)Fructose-6-phosphate & Glyceraldehyde-3-phosphate

Front 3

Importance of NADPH in Liver

Back 3

Drug metabolism
- cytocrome p450
- induce/inhibit drug met

Front 4

Importance of NADPH in Neutrophils

Back 4

NADPH oxidase used to kill bacteria

Front 5

Importance of NADPH in Erythrocyte

Back 5

RBCs have increased O2 therefore ROS are a problem. If accumulates we can get hgb denaturation (heinz bodies) & membrane damage (hemolytic anemia)

Front 6

Glutathione redox cycle

Back 6

Glutathione reductase regenerates reduced glutathione. Glutathione peroxidase reduces H2O2 to water.

Front 7

When will we often see signs of glucose-6-phosphate dehydrogenase deficiencey?

What is the result?

Back 7

In oxidative stress
-fava beans
-certain drugs
-infections

Heinz bodies & Hemolysis