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16 Cards in this Set
- Front
- Back
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Eicosanoids are produced from? |
Fatty acid oxygenation (mostly arachidonic acid) |
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What is the pathway to get Arachidonic Acid (AA) |
cytokine stimulus or mechanical trauma increase Ca level Phospholipase A2 (PLA2) Arachidonic acid |
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Arachidonic acid --> Prostaglandins and Thromboxane? |
Cyclooxygenase |
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Arachidonic acid --> Leukotrienes |
Lipoxygenase |
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2 kinds of COX? What is the difference? |
COX1 = constitutive COX. COX2 = inducible COX |
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What does COX 1 and COX 2 regulate? |
COX 1 = GI cytoprotection and renal blood flow. COX 2 = Pain, Inflammation, Fever |
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What prostanoids do Mast cells release? |
PGD2, PGE2, PGI2 |
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Action of Prostacyclin PGI2 |
comes from vascular endothelium vasodilation inhibition of platelet aggregation |
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PGD2 |
from mast cells vasodilation inhibit platelet aggregation |
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Thromboxane |
from platelets vasoconstriction platelet aggregation |
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PGE stimulates? |
contraction of bronchial and GIT smooth muscle relax bronchial, vascular and GIT smooth muscle inhibit gastric acid release, incr. gastric mucus secretion contraction of pregnant uterus |
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PGE2 is a mediator of? |
FEver |
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PGF2alpha |
acts on FP receptors in smooth muscle and corpus luteum. produced in uterus of non pregnant mares = causes luteolysis causes contraction of uterine muscles during parturition. |
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PGF2alpha used for? |
reproduction. 2 injections given 10-12 days apart. Majority of animals in oestrus 3-5 days after second injection Also opthalmology - treatment of glaucoma. |
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What does parturition mean? |
giving birth. |
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What is PGE used for? |
Misoprostol = stable analogue of PGE which is used for cytoprotective effects in gastric ulceration. = more mucus production and more gastric blood flow. |
