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54 Cards in this Set

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HLA DR5
pernicious anemia & juvenile RA
HLA DR2
Goodpasture syndrome, allergy, multiple sclerosis, & narcolepsy
HLA DR3
celiac sprue, type I diabetes mellitus, & SLE
HLA DR4
pemphigus vulgaris, RA, type I diabetes
HLA DR7
steroid-responsive nephrotic syndrome
HLA B27
psoriasis, ankylosing spnondylitis, inflammatory bowel disease, Reiter's syndrome (PAIR)
HLA B8
Graves' disease, celiac sprue
HLA DR5
pernicious anemia (B12 deficiency), Hashimoto's thyroiditis
antinuclear antibodies (ANA)
SLE
anti-dsDNA, anti-Smith
specific for SLE
antihistone
drug-induced SLE
anti-IgG (rheumatoid factor)
rheumatoid arthritis
antineutrophil (C-ANCA, P-ANCA)
vasculitis
anticentromere
scleroderma (CREST)
anti-Scl-70
scleroderma (diffuse)
antimitochondrial
primary biliary cirrhosis
antigliadin
celiac disease
anti-basment membrane
Goodpasture's
anti-epithelial cell
pemphigus vulgaris
antimicrosomal
Hashimoto's thyroiditis
anti-Jo-1
polymyositis, dermatomyositis
IL-1
secreted by macrophages; stimulates T cells, B cells, neutrophils, fibroblasts, and epithelial cells to grow, differentiate or synthesize specific products
this cytokine is an endogenous pyogen
IL-1
IL-2
secreted by Th cells; stimulates growth of helper and cytotoxic T cells
IL-3
secreted by activated T cells; supports the growth and differentiation of bone marrow stem cells
this cytokine has a function similar to GM-CSF
IL-3
IL-4
secreted y Th cells; promotes growth of B cells; enhances cass switching of IgE and IgG
IL-5
secreted by Th cells; promotes differentiation of B cells; enhances class switching of IgA & stimulates production and activation of eosinophils
IL-6
secreted by Th cells and macrophages; stimiulates production of actute-phase reactants and immunoglobulins
IL-8
major chemotactic factor for neutrophils
IL-10
secreted by Th2 cells; stimulates Th2 while inihibiting Th1
IL-12
secreted by B cells and macrophages; activates NK and Th2 cells
gamma-interferon
secreted by Th cells; stimulates macrophages
TNF-alpha
secreted by macrophages; increases IL-2 receptor synthesis by Th cells; increases B cell proliferation; attracts and activates neutrophils; stimulates dendritic cell migration to lymph nodes
what are the cell surface proteins on helper T cells?
CD4, TCR, CD3, CD28, CD40L
cell surface proteins on cytotoxic T cells
CD8, TCR, CD3
cell surface proteins on B cells
IgM, B7, CD19, CD20, CD40, MHC II
cell surface proteins on macrophages
MHC II, CD14, receptors for Fc and C3b
cell surface proteins on NK cells
receptors for MHC I, CD 16
cell surface protein on all cells except mature RBCs
MHC I
complement proteins involved in viral neutralization (4)
C1, C2, C3, C4
complement protein responsible for opsonization
C3b
complement proteins involved in anaphylaxis
C3a, C5a
complement protein responsbile for neutrophil chemotaxis
C5a
complement proteins involved in cytolysis by MAC
C5b-9
rheumatoid factor and anti-SS-A
Sjogren syndrome
HLA A3
primary hemochromatosis
high antibody titers to ribonucleoprotein (RNP); low titer RF and anti-ssDNA
mixed connective tissue disease
c-ANCA
Wegener's granulomatosis
anti-Ro/anti-SS-A
Sjogren's syndrome
anti-SS-B
Sjogren's syndrome
what instructs macrophages to become epitheliod and multinucleated giant cells?
interferon-gamma
what is the most specific marker for NK cells?
CD56; also CD16
cytokine that mediates the isotype switch to IgE in B lymphocytes
IL-4, produced by Th2 cells