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54 Cards in this Set
- Front
- Back
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HLA DR5
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pernicious anemia & juvenile RA
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HLA DR2
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Goodpasture syndrome, allergy, multiple sclerosis, & narcolepsy
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HLA DR3
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celiac sprue, type I diabetes mellitus, & SLE
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HLA DR4
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pemphigus vulgaris, RA, type I diabetes
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HLA DR7
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steroid-responsive nephrotic syndrome
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HLA B27
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psoriasis, ankylosing spnondylitis, inflammatory bowel disease, Reiter's syndrome (PAIR)
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HLA B8
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Graves' disease, celiac sprue
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HLA DR5
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pernicious anemia (B12 deficiency), Hashimoto's thyroiditis
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antinuclear antibodies (ANA)
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SLE
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anti-dsDNA, anti-Smith
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specific for SLE
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antihistone
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drug-induced SLE
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anti-IgG (rheumatoid factor)
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rheumatoid arthritis
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antineutrophil (C-ANCA, P-ANCA)
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vasculitis
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anticentromere
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scleroderma (CREST)
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anti-Scl-70
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scleroderma (diffuse)
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antimitochondrial
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primary biliary cirrhosis
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antigliadin
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celiac disease
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anti-basment membrane
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Goodpasture's
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anti-epithelial cell
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pemphigus vulgaris
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antimicrosomal
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Hashimoto's thyroiditis
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anti-Jo-1
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polymyositis, dermatomyositis
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IL-1
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secreted by macrophages; stimulates T cells, B cells, neutrophils, fibroblasts, and epithelial cells to grow, differentiate or synthesize specific products
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this cytokine is an endogenous pyogen
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IL-1
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IL-2
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secreted by Th cells; stimulates growth of helper and cytotoxic T cells
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IL-3
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secreted by activated T cells; supports the growth and differentiation of bone marrow stem cells
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this cytokine has a function similar to GM-CSF
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IL-3
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IL-4
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secreted y Th cells; promotes growth of B cells; enhances cass switching of IgE and IgG
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IL-5
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secreted by Th cells; promotes differentiation of B cells; enhances class switching of IgA & stimulates production and activation of eosinophils
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IL-6
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secreted by Th cells and macrophages; stimiulates production of actute-phase reactants and immunoglobulins
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IL-8
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major chemotactic factor for neutrophils
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IL-10
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secreted by Th2 cells; stimulates Th2 while inihibiting Th1
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IL-12
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secreted by B cells and macrophages; activates NK and Th2 cells
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gamma-interferon
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secreted by Th cells; stimulates macrophages
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TNF-alpha
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secreted by macrophages; increases IL-2 receptor synthesis by Th cells; increases B cell proliferation; attracts and activates neutrophils; stimulates dendritic cell migration to lymph nodes
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what are the cell surface proteins on helper T cells?
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CD4, TCR, CD3, CD28, CD40L
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cell surface proteins on cytotoxic T cells
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CD8, TCR, CD3
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cell surface proteins on B cells
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IgM, B7, CD19, CD20, CD40, MHC II
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cell surface proteins on macrophages
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MHC II, CD14, receptors for Fc and C3b
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cell surface proteins on NK cells
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receptors for MHC I, CD 16
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cell surface protein on all cells except mature RBCs
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MHC I
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complement proteins involved in viral neutralization (4)
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C1, C2, C3, C4
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complement protein responsible for opsonization
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C3b
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complement proteins involved in anaphylaxis
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C3a, C5a
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complement protein responsbile for neutrophil chemotaxis
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C5a
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complement proteins involved in cytolysis by MAC
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C5b-9
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rheumatoid factor and anti-SS-A
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Sjogren syndrome
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HLA A3
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primary hemochromatosis
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high antibody titers to ribonucleoprotein (RNP); low titer RF and anti-ssDNA
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mixed connective tissue disease
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c-ANCA
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Wegener's granulomatosis
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anti-Ro/anti-SS-A
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Sjogren's syndrome
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anti-SS-B
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Sjogren's syndrome
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what instructs macrophages to become epitheliod and multinucleated giant cells?
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interferon-gamma
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what is the most specific marker for NK cells?
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CD56; also CD16
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cytokine that mediates the isotype switch to IgE in B lymphocytes
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IL-4, produced by Th2 cells
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