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18 Cards in this Set
- Front
- Back
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Zidovudine (AZT)
may need epogen |
Retrovir NRTI
300mg q12 PO or IV GI INTOLERANCE, feet/hands pigmented Macrocytic anemia, neutropenia, |
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Lamivudine (3TC)
also for HEP B |
Epivir NRTI
150 bid or 300 qd minimal side effects no DDI |
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Abacavir (ABC)
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Ziagen NRTI
300 q12 or 600 qd *HYPERSENSITIVITY, rash/fever, ETOH increases levels by 41% no renal dose adjustment needed |
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Didanosine (ddl)
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Videx NRTI
400 qd without food pancreatitis, peripheral neuropathy |
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NRTI class
MOA ADR Dose adjustment |
interfere with RNA-dependent DNA polymerase causing chain term. and stopping viral replication
Lactic acidosis, severe hepatomegaly with steatosis and most pts need renal dose adjustment (excpt abacavir) |
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Combivir (NRTI combo)
BID |
Zidovudine + lamivudine
300/150mg BID |
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Trizivir (NRTI combo)
BID |
Zidovudine + lamivudine + abacavir
BID |
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Truvada (NRTI combo)
daily |
tenofovir + emtricitabine
qd |
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Epzicom (NRTI combo)
daily |
Lamivudine + abacavir
qd |
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Stavudine (d4T)
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Zerit NRTI
40mg BID >60kg 30mgBID <60kg pancreatitis, peripheral neuropathy, lipodystrophy, dyslipidemia |
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Zalcitabine (ddC)
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Hivid NRTI
0.75mg q8hr pancreatitis, peripheral neuropathy |
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Tenofovir (TDF)
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Viread NRTI
300mg QD Renal insuff. |
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Emtricitabine (FTC)
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Emtriva NRTI
200mg QD minimal side effects, but hyperpigmentation of soles of hands and feet no DDI |
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3 NRTI-based regimen
(only when preferred PI or NNRT regimen cannot be used) |
Abacavir + Zidovudine + lamivudine
Trizivir |
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NNRTI-based regimen
Preferred |
Efavirenz +(lamivudine or emtricitabine)+(zidovudine or tenofovir)
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NNRTI-based regimen
Alternatives |
Efavirenz+ (lamivudine or emtricitabine) + (didanosine or abacavir or stavudine)
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NNRTI-based regimen
if pregnant 1st trimester or at risk of pregnancy *avoid efavirenz Sustiva |
Nevirapine+ (lamivudine or emtriciabine)+ (zidovudine + or stavudine or didanosine or abacavir or tenofovir)
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Protease inhibitor
Preferred regimens |
Lopinavir + ritonavir (kaletra)
+ lamivudine or emtricitabine + zidovudine |
