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56 Cards in this Set
- Front
- Back
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Mavoric |
Selentry CCR5 receptor antagonist, prevents virion binding. Hepatotoxicity, cough, dizzy, GI effects 300mg BID , 150mg , 600mg |
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Enfurvitide |
Fuzeon Refridgerate Fusion Inhibitors binds to GP41 to prevent viral entry. injection site rxn, hypersensitivity, bacterial pnuemonia. 90 mcg (SQ) BID LAST RESORT |
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NNRTIs MOA |
works at site of Reverse Transcriptase, bind to enzyme ..inhibits RNA from becoming DNA |
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NRTIs MOA |
targets RTranscriptase causes the termination of DNA chain elongation |
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NNRTIs Side effects |
Steven Johnson Syndrome, Hepatotoxicity, Rash |
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NRTIs side effects |
Lactic Acidosis, Hepatic Steatosis |
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Integrase Strand Transfer Inhibitor |
Inhibits viral DNA integration in CD4 DNA |
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EVG/ Cobic/TDF/ FTC |
Stribild |
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Stribild dosing |
1 tablet QD take with food CrCl > 70 ml/min |
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Abacavir |
Ziagen (ABC) |
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Protease Inhibitors |
Blocks elongation of viral chain protiens |
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Protease Inhibitor side effects |
3A4 substrate & inhibitor hepatoxicity, lipohypertrophy, GI, MI, Stroke, Renal Stone (Water), Boosted PI's- dyslipidemia |
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Atazavinir |
(ATV) Rayataz 400mg QD or ATV 300mg + RTV 100mg QD |
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Idinavir |
(IDV) Crixavan 800 mg Q8H or IDV 800mg + (RTV 100mg/ 200mg) BID |
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Darunivir |
(DRV) Prezista * (sulfonamide) DRV 600mg + RTV 100 mg BID |
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Fosamprenivir |
(FAMP, FPV) Lexiva *(sulfonamide) 1400 mg BID FPV 1400mg + RTV 200mg |
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Fixed Dose NRTI |
Epicscom Truvada Trizvir Combovir |
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Episcom |
Lamuvidine/Abacavir 1 tab QD NRTI |
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Truvada |
Emtricabine/ Tenofovir 1 tab QD NRTI |
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Trizvir |
Zidouvadine/Lamuvidine/ Abacavir 1 tab BID NRTI |
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Combovir |
Zidouvudine/ LAmouvidine 1 tab BID NRTI |
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Rescriptor |
(DLV) Delaviridine 400 mg Q8H NNRTI |
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Sustiva |
(EFV) Efavirenz 200 mg QD NNRTI Eat on an empty stomach at bedtime |
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Side effects of Sustiva |
Depression, Vivid Dreams, CNS issues |
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Intelence |
ETR Intelence 200 mg QD NNRTI |
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Viramune |
(NVP) Nevirapine / XR 200mg QD for 14 day Test period then 200 mg BID XR 400 mg/ day NNRTI |
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Side effects of Viramune |
Very bad rash and hepatotoxicity must take test dose to make sure pt can tolerate drug. |
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Endurant |
Rifpivirine (RPV) 25 mg / day Take with food (needs acidic environment) NNRTI |
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KAletra |
Zopinavir (LPV) / Ritonavir (RTV) 400mg/100mg or 800mg/200mg PI |
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Viraept |
Nelfinavir (NFV) 1250mg BID or 750 mg Q8H PI |
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Invarase |
Saquinivir ( SQV) 100 mg + RTV 100mg Q12H PI |
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\Norvir |
Ritinovir (RTV) 100-400 mg/day BID for booster |
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Side effects of Norvir |
Sever GI effects |
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Aptivus |
(TPV) Tipranovir *Sulfonamide (must be refridgerated) 500 mg + RTV 200 mg BID |
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Factors to consider before therapy |
Pre treatment HIV RNA levels CD4 count < 200 (AIDS) HIV genotype results Hypersensitivity Pt adherence Pt Preferences Disease states (CVD,Dyslipidemia,Osteoporosis,Hep C MEntal illness Pregnancy |
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Which drug contains a sulfonamide? |
Prezista |
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Regimens requiring food |
ATV/r or ATV/c DVR/r or DVR/c EVG/c/TDF/FTC RPV/TDF/FTC |
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Which drug causes a dangerous side effect in Cardiovascular disease pt |
Abacavir (ABC) Ziagen causes MI * avoid ABC and LPV/r Regimens |
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Which drug is beneficial in Lipid disorder patients |
TDF |
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Side effects of Tedenofir |
decrease bone density, Renal tubulopathy, Urine phosphate wasting, osteomalacia Alt ABC/3TC |
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Which drugs are avoided in psychiatric illness? |
Avoid EFV (vivid dreams, suicidal) |
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What drugs are avoided in Drug addiction |
EFV effects methadone = decreases concentrations of methadone |
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Which NRTI drugs are preferred in pregnancy? |
ABC and 3TC, TDF &FTC, TDF &3TC or ZDV/3TC |
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Which Protease Inhibitors are reccommended in pregnancy? |
ATV/r or DRV/r BID |
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Which NNRTIs are used in pregnancy? |
EFV (8 weeks) or RPV/ TDF/ FTC |
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Which INSTI drugs are used in pregnancy |
RAL (BID) |
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How to treat patients with Hep C? |
screen all HIV pt for HEPC, Initiate ART regardless of CD4, Delay HCV tx until HIV is stable. |
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Which drugs are used in Hep B and HIV |
TDF, FTC and 3TC TDF is the mainstay in Hep B and HIV |
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Tuberculosis Tx interaction with HIV |
Rifampin - 3A4 inducer will cause decrease in PI, INSTI, and RPV |
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Tuberculosis treatment in HIV |
Rifabutin(Rifabul) Mycobutin with EFV based regimen |
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DTG side effects |
insomnia, and headache |
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Elvitegravir side effects |
GI , Nausea&vomiting, Headache |
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Raltegravir side effects |
Creatine Kinase increased, myositis, Rhabdomysis, skin rxn is rare. |
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EFV side effects |
NNRTI CNS , H/A, depression, dizziness, vivd dreams |
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Side effects of PIs |
Sulfonamide rxn (Darunivar/Ritonavir) or (Darunivar/cobistat) Reversible hyperbillirubin, GI (Atazavanir/ Ritanovir or Atazanavir/cobicstat) GI, insulin resistance, dyslipedemia, MI (Lopinavir/Rotinavir) |
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Which drugs come as a fixed dose |
DTG/ABC/3TC or EFV/TDF/FTC |
