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43 Cards in this Set
- Front
- Back
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CD4 Goal
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>500 cells/mm^3
500-1300 cells/mm^3 |
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AIDS definition
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CD4 count <200 at any point
Or having AIDS-defining illness+HIV (TB, Cryptococcus, Kaposi's sarcoma, Hisetoplasmosis............) |
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Abacavir
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NRTI
ABC - Ziagen Less Lactic Acidosis/Hepatic Steatosis Hypersensitivity (do HLA-B*5701 Testing) Possible increased risk of MI |
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Emtricitabine
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NRTI
FTC - Emtriva Less Lactic Acidosis/Hepatic Steatosis Renal dosing if CrCl < 50ml/min |
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Lamivudine
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NRTI
3TC - Epivir Less Lactic Acidosis/Hepatic Steatosis Renal dosing if CrCl < 50ml/min |
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Tenofovir
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NRTI
TDF - Viread Less Lactic Acidosis/Hepatic Steatosis Renal dosing if CrCl < 50ml/min (nephrotoxicity): Osteoporosis, Phosphorus Wasting, Fanconi Syndrome |
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Zidovudine
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NRTI
AZT - Retrovir Only HIV med available IV One of preferred drugs during pregnancy and peds Bone marrow suppression Leukopenia Endocrine AE GI AE |
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Trizivir
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Abacavir + Lamivudine + Zidovudine
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Combivir
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Lamivudine + Zidovudine
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Truvada
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Emtricitabine + Tenofovir
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Epizicom
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Abacavir + Lamivudine
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Efavirenz
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NNRTI
EFV - Sustiva Teratogenic! Neuropsychiatric Symptoms Adherence critical due to resistance Empty Stomach Rash |
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Etravirine
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NNRTI
ETR - Intelence With food Rash |
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Rilpivirine
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NNRTI
RPV - Edurant Must take with 500 kcal/dose Only effective if viral load is less than 100,000 Rash Do not give with PPI's |
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Atripla
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Emtricitabine + Tenofovir + Efavirenz
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Complera
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Emtricitabine + Tenofovir + Rilpivirine
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Atazanavir
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PI
ATV - Reyataz Hyperbilirubinemia QTC prolongation Do not give with PPI's |
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Darunavir
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PI
DRV-Prezista |
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Lopinavir/Ritonavir
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PI
LPV/RTV - Kaletra Preferred drug for pregnancy (bid only) QTC prolongation |
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PI MoA
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Prevent maturation of virus
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Enfuvirtide
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Entry Inhibitor
Fuzeon MoA involves gp41 Injected SQ bid (reconstitution, injection site reactions) |
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Maraviroc
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Entry Inhibitor
Selzentry CCR5 (trophism test required) Hepatotoxicity Renal dosing Rash |
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Elvitegravir
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Integrase inhibitor
Part of Stribild C/I if CrCl <70 ml/min |
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Raltegravir
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Integrase Inhibitor
Isentress NO DRUG INTX Bid dosing only |
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Stribild
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Emtricitabine + Tenofovir + Elvitegravir + Cobicistat
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Preferred Initial Treatment Regimens
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Atripla (Efavirenz/Tenofovir/Emtricitabine)
(Atazanavir/ Ritonavir/ Tenofovir/ Emtricitabine) Darunavir/Ritonavir/ Tenofovir/ Emtricitabine Raltegravir/Tenofovir/Emtricitabine (bid) |
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Preferred Initial Treatment in Pregnancy
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Lopinavir/Ritonavir (bid) + Zidovudine/Lamivudine
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NRTI class Notes
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Lactic Acidosis/Hepatic Steatosis
Lipodystrophy |
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Didanosine
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NRTI
Pancreatitis Hepatotoxicity |
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Stavudine
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Highest incidence of lipodystrophy
Pancreatitis |
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NNRTI Class Notes
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Rash
Only 1 mutation to resistance Hepatotoxicity |
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Protease inhibitors Class Notes
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Take with food
Boost with ritonavir GI AE Hyperlipidemia (treat with statins) Endocrine AE Bleeding risks in hemophiliacs Hepatotoxicity Osteonecrosis |
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Nelfinavir
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PI
Teratogenic |
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Saquinavir
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PI
Highest Pill Burden Very serious GI intolerance QTc prolongation |
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Tipranavir
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PI
Liver toxicity Intracranial Hemorrhage |
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Statins
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Avoid Simvastatin and Lovastatin
Atorvastatin at or below 20 mg is acceptable |
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ED Drugs
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Halve dose and extend interval to 48-72hrs
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Antibiotics
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Azithromycin is best macrolide
FQ are ok (except with Didanosine) Don't use rifampin (do rifabutin) |
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Antiepileptics
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Use Gabapentin, Keppra, Topiramate
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Long half life HIV drugs
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Efavirenz
Nevirapine (NRTI) Rilpivirine |
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Who qualifies for Pre-Exposure Prophylaxis
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Men who have sex with men
Heterosexual sero-discordant couples IVDA |
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Pre-Exposure Prophylaxis Treatment Option
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Truvada
-In REMS program -Limited to 90 days supply prescribing |
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Post-Exposure Prophylaxis
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Must be started within 72 hours
HIV testing at baseline, 6 weeks, 3 months, 6 months Raltegravir+Truvada x 28 days |
