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56 Cards in this Set
- Front
- Back
CCR5 anatagonist
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maraviroc...must be a macrophage x5 virus...must see if patient is trophic
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raltegravir
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integrase inhibitor which has side effect of unfavorable lipid profile
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GI interance and p450 inhibitors therefore increases blood levels of other drugs
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protease inhiibitor
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lipodystophy and hyperglycemia
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saqinavir indinovir and amprenovir
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pancreatits as a protease inhibitor
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ritonavir
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nephrolithiasis...HIV patient with kidney stones is taking...
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indivavir
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NRTI what cause pacreatits and peripheral neuropathy
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didavudine, zalcitabine, stauvudine
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NRTI that cause hepatic steatosis
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didavudine and stauvudine
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NRTI causing hypersensitivity reactions is
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abacavir
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bone marrow suppressing fixed by GM-CSF and megaloblastic anemia
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zidovudine
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class effect is rash
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NNRTI... no need to activate in cell
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false positive test for cannibinoids
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efavirenz
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confusion
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efavirenz
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Nevir, ef with dec
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NNRTI
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inhibit fusuion and entry into CD4 cell by blocking (env)gp41
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enFUvirtide...FU=fusion
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causes hypersensitivaty at injection site and increases risk for pneumonia
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enfuvirtide
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lactic acidosis
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NRTI except abacavir (AZT, didanosine, zalcitabine, stauvudine, lamivudine)
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GI intolenace
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navir
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pancreatitis
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ritonavir, didanosine, zalcitabine, stauvudine
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peripheral neuropathy
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didanosine, zalciabine, stauvudine
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megaloblastic anemia
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zidovudine
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rash
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NNRTI
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hyperglycemia, diabetes, lipid abnormalities
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saquinavir, indinovir, amprenavir
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bone marrow suppression
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zidovudine
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occupational exposure
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zidovudine and lamivudine
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ADD
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modafinil
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atypical antipsych that cause diabetes and weight gain
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olanzapine, clozapine, quitapine
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dopamine antagonists in the brain do what do cAMP levels
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increase cAMP because D2 is a Gi receptor
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gene mutated in those who get malignant hyperthermia
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RYR1 gene
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progression on typical neuroleptic EPS side effects...what happens after hours
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dystonis
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progression on typical neuroleptic EPS side effects....what happens after days
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PD like symptoms
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progression on typical neuroleptic EPS side effects...what happens after weeks
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spasticity and restlessness (akinesia
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progression on typical neuroleptic EPS side effects...whatt happens after months
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tarditive dyskinesia... irrvesible looking at the mouth
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treatment for bipolar
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lithium, valproic acid, carbamazopine, lamotrigine
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contraindicated in pt with bipolar
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SSRI
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drugs that increase the blood levels of lithium
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ACEi, NSAIDS, diuretics (either decrease water or decrease GFR
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lithium side effects (kidney excreted)
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DI, hypothyroid, muscle excitability and agitiation, tremor, heartblock
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post partum time separation
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2 weeks, past two weeks, psycholsis
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drugs that decrease the seizure threshold
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BII...buproprim, imipenum, INH
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TCA unique uses...imipramine? clomipramine, nortryptyline, desipramine?
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imipramine=bed wet, clomipramine=OCD, nortryptline= less anti cholinergic, desipramine=least sedating
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TCA tox and treatment
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CCC...spasm to hyperpyrexia...give naHCO2
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fluoxatine
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long acting SSRI
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cita, sertparotxitine, fluoxitine
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SSRi
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social phobia
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SSRI
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when SSRI taken with MAOi, SNRI, sibutramine....what do u give
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this is serotonin syndrome...cool them down then give cyproheptidine a (serotonin antagonist)
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nefazodone, milnacipran, sibutramine
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SNRI...sibutramine is used for weight loss
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dulo adverse effect
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diabetic periph neuropathy
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phenelzine, tranylcypromine, isocarboxazid, selegine and capsone
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MAOi used for atypical depression and hypochondriasis
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MAOi worse case is malignant hypertension
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with wine and cheese (tyrosine not broken down by MAO in cut)...beta-agonists...must give 2 weeks wash out period
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A/E of TCA (amytriptyline)
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inhibit reuptake of NE and serotonin, anti alpha effects cause hypotension, block fast Na channels causing conduction defects, block muscarinic recpetors causing delirum hot flush, block histamine causing sedation
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alpha 2 blocker and 5-HT2 and 3 antagonist tox... (mert wont stop eating or sleeping)
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mirtazapine causes sedation increased appetite therefore use in depressed with sleeping problems or depressed with eating problems
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Trazodone and Maprotiline
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inhibit serotnin and NE reuptake respectivly...trazadone used for insomnia too
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atypical neuroleptic that causes prolonged QT
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ziprasidone
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make sure you check LFT on
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INH and carbamazipine
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thyroid tox
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lithium and amioderone
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clozipine
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seizures and aplastic crisis
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