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18 Cards in this Set
- Front
- Back
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abacavir SE
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hypersensitivity
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didanosine SE
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pancreatitis, retinal changes
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efavirenz SE
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CNS tox, GI intolerance
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indinavir SE
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nephroliathiasis, hyperglycemia
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navirapine SE
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hepatotox, skin rash
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drugs that affect liver metabolism
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inducer (efavirenz, nevirapine) inhibitor (delavirdine, efavirenz, PI)
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common SE of PI
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lipodystrophy
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common side effects of NRTI
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mitochondrial tox, lactic acidosis with hepatic steatosis, disorders of lipid metabolism
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rationale for combination of lopinavir/ritonavir
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ritonavir inhibits cyp3a4 mediated metabolism which results in a boost in lopinavir, ritonavir is a pharmacological enhancer
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NRTI
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abacavir, didanosine, emtricitibine, lamivudine, stavudine, tenofovir, zalcitabine, zidovudine
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NNRTI
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nevirapine, efavirenz, delavirdine
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PI
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Ataznavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
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FI
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enfuvirtide
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EI
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maraviroc
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II
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raltegravir
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NRTI MOA
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requires phosphorylation by host enzymes, competitive inhibition of HIV RT, Incorporated into viral DNA causing termination
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NNRTI MOA
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bind to and inhibit HIV RT, do not compete with nucleoside triphosphate, do not require phosphorylaiton for activation, metabolized by cyp 450 system and can act as inducers or inhibitors of p450 enzymes
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PI MOA
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prevent cleavage of gag-pol polyprotein resulting in the production of immature noninfectious viral particle
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