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15 Cards in this Set

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Fusion Inhibitors MOA?
Fusion Inhibitors work outside the cell to prevent HIV from entering the CD4 cell by blocking fusion of the outer membrane of the virus with the cell membrane.
NRTI's MOA?
Act as false substrate for reverse transcriptase causing chain termination. The DNA is incomplete therefore no further HIV replication occurs.
NNRTI's MOA?
Binds to reverse transcriptase and inhibits the enzyme. Prevent conversion from RNA to DNA (Act at same location as NRTI's, but use completely different MOA).
PI's MOA?
Prevent HIV from being successfully assembled and released from the infected CD4 cell.
Fussion Inhibitors
Fuzeon (enfuvirtide) binds to GP41 and stops virus from entering CD4 cell
Dose: 90 mg Q12h injectable
Side-effects: nodules, cysts, bacterial pneumonia
Cost: $20,000/year
Last line agent
NRTI's
Retrovir (zidovudine, AZT)
Videx (didanosine, DDI)
Zerit (stavudine,D4T)
Epivir (lamivudine, 3TC)
Ziagen (abacavir, ABC)
Emtriva (emtricitabine, FTC)
Viread (tenofovir, TDF)
Black box warnings for NRTIs?
(all NRTIs)
All NRTI's have black box warnings for:
Lactic acidosis (due to blockage of DNA gyrase)
Hepatic stenosis
Retrovir (zidovudine)
Dose: 300mg BID
Black box warning: (above)+ bone marrow supression (eg. granulocytopenia, severe anemia)
Thymidine
Videx (didanosine)
Dose: >60kg:400mg BID
<60kg:250mg QD
Side-effects:Neuropathy,N/V/D
Mitochondria toxicity
Black-box:pancreatitis
Patient education:take on empty stomach
Adenosine
Zerit (stavudine)
Dose: >60kg:40mg BID
<60kg:30mg BID
Side-effects:Elevated trigs, neuropathy, lypoathrophy, pancreatitis, Mitochondrial toxicity.
Thymidine
Epivir (lamivudine)
Dose: 150mg BID or 300mg QD
Black-box:hepatic flare up with removal
Never use with emtriva
Cytosine
Ziagen (abacavir)
Dose: 300mg BID or 600mg QD
Black-box:Hypersensitivity!!!
Do not rechalange!
Alcohol Increases level by 41%
Guanine
Emtriva (emtricitabine)
Dose: 200mg QD
Side-effects: hyperpigmentation
Black-box: flare up with removal
Never use with Epivir
Cytosine
Viread (tenofovir)
Dose: 300mg QD with food
Warning: renal insufficiency (watch CrCl)
Black-box: hepatic flare-up with removal
Combinaition therapy available?
Combivir (AZT,3TC)
Trizivir (AZT, 3TC, ABC)
Truvada (TDF, FTC)
Epzicom (ABC, 3TC)
Only combo agent that spends across classes:
Atripla (efavirenz, emtricitabine, tenofovir)