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15 Cards in this Set
- Front
- Back
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Fusion Inhibitors MOA?
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Fusion Inhibitors work outside the cell to prevent HIV from entering the CD4 cell by blocking fusion of the outer membrane of the virus with the cell membrane.
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NRTI's MOA?
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Act as false substrate for reverse transcriptase causing chain termination. The DNA is incomplete therefore no further HIV replication occurs.
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NNRTI's MOA?
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Binds to reverse transcriptase and inhibits the enzyme. Prevent conversion from RNA to DNA (Act at same location as NRTI's, but use completely different MOA).
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PI's MOA?
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Prevent HIV from being successfully assembled and released from the infected CD4 cell.
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Fussion Inhibitors
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Fuzeon (enfuvirtide) binds to GP41 and stops virus from entering CD4 cell
Dose: 90 mg Q12h injectable Side-effects: nodules, cysts, bacterial pneumonia Cost: $20,000/year Last line agent |
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NRTI's
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Retrovir (zidovudine, AZT)
Videx (didanosine, DDI) Zerit (stavudine,D4T) Epivir (lamivudine, 3TC) Ziagen (abacavir, ABC) Emtriva (emtricitabine, FTC) Viread (tenofovir, TDF) |
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Black box warnings for NRTIs?
(all NRTIs) |
All NRTI's have black box warnings for:
Lactic acidosis (due to blockage of DNA gyrase) Hepatic stenosis |
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Retrovir (zidovudine)
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Dose: 300mg BID
Black box warning: (above)+ bone marrow supression (eg. granulocytopenia, severe anemia) Thymidine |
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Videx (didanosine)
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Dose: >60kg:400mg BID
<60kg:250mg QD Side-effects:Neuropathy,N/V/D Mitochondria toxicity Black-box:pancreatitis Patient education:take on empty stomach Adenosine |
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Zerit (stavudine)
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Dose: >60kg:40mg BID
<60kg:30mg BID Side-effects:Elevated trigs, neuropathy, lypoathrophy, pancreatitis, Mitochondrial toxicity. Thymidine |
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Epivir (lamivudine)
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Dose: 150mg BID or 300mg QD
Black-box:hepatic flare up with removal Never use with emtriva Cytosine |
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Ziagen (abacavir)
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Dose: 300mg BID or 600mg QD
Black-box:Hypersensitivity!!! Do not rechalange! Alcohol Increases level by 41% Guanine |
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Emtriva (emtricitabine)
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Dose: 200mg QD
Side-effects: hyperpigmentation Black-box: flare up with removal Never use with Epivir Cytosine |
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Viread (tenofovir)
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Dose: 300mg QD with food
Warning: renal insufficiency (watch CrCl) Black-box: hepatic flare-up with removal |
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Combinaition therapy available?
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Combivir (AZT,3TC)
Trizivir (AZT, 3TC, ABC) Truvada (TDF, FTC) Epzicom (ABC, 3TC) Only combo agent that spends across classes: Atripla (efavirenz, emtricitabine, tenofovir) |
