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16 Cards in this Set
- Front
- Back
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Gp120/gp41
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they bind to the cells to cause the infection
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what does tat and rev do
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RNA synth. and trans to cytoplasm
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what is nef protien
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important for pathogenicity
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pol does what
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encodes reverse transcriptase major target of NRTIs
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what is the primary receprto for attachment of HIV1
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CD4
CCR5 |
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how is immune to HIV
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mutant CCR5
usually european whites |
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HIV was cured once how
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bone marrow transplant from a person with CCR5 mutation
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how is HIV diagnosed
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antibody capture ELISA to detect antiHIV antibody detects IgG but takes time to get that in the blood so u have to wait a while before u can find out, must wait 2 too 14 weeks
western blot is used to confirm because ELISA can give false pos. this test will not work on newborns of infected mothers PCR to detect proviral DNA in peripheral blood cells in new borns nucleic acids test can be used to find disease 12 days after exposure |
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what is quantititive RT-PCR used for
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used to measure viral load for treatment
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transmission of HIV ?
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blood, needle sharing, tattoing
blood transfusino semen vaginal seretions breast milk |
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what is used to preven mom child transmission
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nevirapine
short term combination therapy |
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what is the definition of AIDS
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HIV infection and less than 200 CD4 t/mm
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who are long term non progressors
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HLA-b57
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what is the most common killer in HIV
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pneumocystis jirovici-fungal disease caused pneumonia
esophageal candidissis-generally not life threatening Kaposi sarcoma oral hairy leukoplakia cytomegalovirus retinitis mycobacterium avian complex TB herpies JC polyomaviris-fatal brain disease molluseumcontagiosum virus B cell lymphomas invasive cervical carcinoma |
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what are the treatments for HIV
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protease inhibitors
NRTIs Fusion inhibtors integrase enzyzme inhibitors CCR5 attachment inhibitors |
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what vaccines can be used in HIV pt
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any vaccine that is inactivated
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