Hiv/aids Products

Front 1

NRTIs

Back 1

Nucleoside analogs

incorporate themselves into the DNA virus

Lactic acidosis & lipoatrophy

>> N/V/D
>> mitochondrial toxicity
>> Renal CL

Front 2

Retrovir

Back 2

Zidovudine (ZDV or AZT)

Anemia

this was the first "Nuke"

>> pregnant women & peds
>> BBW: hemotologic toxicity, myopathy, macrolytic anemia. Monitor CBC
>> Nausea (36%), fatigue, HA, myalgias

Front 3

Epivir

Back 3

Lamivudine (3TC)

Least SE. Well tolerated

>>Hep B

>>Renal Dosing

Front 4

Videx

Back 4

Didanosine (ddI)

take on EMPTY STOMACH. swallow whole. NEVER take alone (rapid resistance)

PANCREATITIS

>>pediatrics
>>peripheral neuropathy

Front 5

Zerit

Back 5

Stavudine (D4T)

MOST LIPOATROPHY

peripheral neuropathy

>> BBW:pancreatitis
>> BID, wt based

Front 6

Ziagen

Back 6

Abacavir (ABC)

HYPERSENSITIVITY (fever & rash). Do not rechallenge
HLA-B*5701

>>counsel s/sx of HSR (flu-like & respiratory). onset 4-6 weeks.

Front 7

Emtriva

Back 7

Emtricitabine (FTC)

**QD**

flourinated analog of 3TC

SE: hyperpigmentation of pams and soles of feet

>>renal dosing, hep B

Front 8

Combivir

Back 8

lamivudine/zidovudine

epivir/retrovir

3TC/AZT

Front 9

Trizivir

Back 9

lamivudine/zidovudine/abacavir

epivir/retrovir/ziagen

3TC/AZT/ABC

Front 10

Truvada

Back 10

emtriva/viread

emtricitabine/tenofovir

**QD**

Front 11

Epzicom

Back 11

Epivir/Ziagen

lamivudine/abacavir

**QD**

Front 12

Viread

Back 12

Tenofovir

NucleoTIDE RTI. 300mg tab

>> Hep B
>> Hydration
>> Renal insufficiency

3TC/AZT

Front 13

NNRTIs

Back 13

BIND to reverse transcriptase

RASH, LFTs

>hepatotoxicity
>no renal dosing
>Cross-resistance

Front 14

Sustiva

Back 14

Efavirenz. **QD**

Gold standard NNRTI

Take on EMPTY STOMACH at HS

TERATOGENIC (>myelomeningocele)

bad vivid dreams (>CNS, neuropsychiatric)

rash

Front 15

Viramune

Back 15

Nevirapine. **BID**

Worst RASH. SJS & TEN (BBW). do not rechallenge

CYP inducer.

>>For W <250, M<400

>>Dose escalation (200mg QD IE then 200mg IR BID or 400mg QD XR)

>>Monitor LFTs q2wks

Front 16

Rescriptor

Back 16

Delavirdine **TID**

rarely used

Front 17

Intelence

Back 17

Etravirine

2nd generation: active against resistant virus!

less rash, no CNS and no teratogenicity.

400mg PO to be taken BID w or w/o food

>>Many Drug interactions w/PIs
>> Take with food
>>Nausea (13.9%), rash (16.9%)

Front 18

Edurant

Back 18

Rilipivirine

Contraindicated with PIs!

>> VL > 100,000
>> NO PPIs b/c required acidic environment
>> rash, depression, take with FOOD

Front 19

Protease Inhibitors

Back 19

Substrate analogs that inhibit the activity of HIV protease and prevent the cleavage of viral proteins

they work at the last stage of the cycle

THEY PREVENT HIV FROM BEING CLEAVED, MATURED, AND RELEASED FROM THE INFECTED CD4+ CELL

Class SEs: DYSLIPIDEMIAS, FAT REDISTRIBUTION, LFTS

>>rash, hepatotoxicity

Front 20

Reyataz

Back 20

Atazanavir **ONCE-A-DAY**

with food

must have low gastic pH. Avoid PPIs, H2RA or antacids

>> most lipid friendly & GI friendly

>> hyperbilirubinemia & kidney stones

>> With FOOD & HYDRATION

Front 21

Norvir

Back 21

Ritonavir

Only low-dose. "BOOSTER"

inhibits the CYP3A-mediated metabolism of other PIs

>> Potent CYP450 inhibitor
>> dyslipidemia
>> with FOOD

Front 22

Aptivus

Back 22

Tipranavir

take with food

BBW: hepatitis, hemorrhage

>> Tx-experienced pt only!
>> sulfonamide moiety (rash)
>> with food, refrigerate caps b4 opening

Front 23

Kaletra **

Back 23

Lopinavir/ritonavir

>>Alternative, QD or BID

>>GI intolerance

>> Diarrhea, hyperlipidemia (esp. TG)

Front 24

Prezista

Back 24

Darunavir

take with food

ADR: skin rash

>>Preferred vs. resistant virus. QD
>>Liver toxicity, sulfa moeity
>>take with food

Front 25

Lexiva

Back 25

Fos-amprenavir

CAN BE QD or BID

ADR: N/V/D

>>Skin rash (19%), GI
>> caution w/sulfa allergy (cross-sensitivity)

Front 26

Viracept

Back 26

Nelfinavir

take with food

>> THE ONLY PI THAT'S NEVER BOOSTED!
>> Pregnancy & children
>> Diarrhea (30-40%) --> empiric loperamide
>> Take with high fat meal to increase absorption

Front 27

Crixivan

Back 27

Indinavir

Risk of kidney stones

>>nephrolithiasis (12%)
>> Hyperbilirubinemia
>> Drink >1.5L - 2L/d
>> Metalic taste, dry skin
>>Unboosted = NO food!

Front 28

>>Invirase

Back 28

>> Saquinavir

>> PR & QT prolongation
>> ECG monitoring, high pill burden (>6)
>> WITH FOOD

Front 29

Fuzeon

Back 29

Infuvirtide

fusion inhibitor

Inhibits gp41

inject 1mL BID SQ into upper arm, thigh, or abdomen. POTENTIAL PAINFUL NODULES @ inj. site (rotate sites)

>>No renal/hepatic dose adj.
>> Salvage therapy

Front 30

Selzentry

Back 30

Miraviroc

CCR5 inhibitor

>>Tropism test
>> P450 substrate
>> BBW: hepatotoxicity +/- allerg rxn

Front 31

Isentress

Back 31

Raltegravir

Integrase inhibitor --> PREVENTS THE COVALENT INSERTION OR INTEGRATION OF HIV-1 DNA INTO THE HOST CELL GENOME

>>No cyp450 interactions
>> BID dosing
>>myopathy & rhabdomyolysis

Front 32

>>Elvitegravir

Back 32

CYP450 substrate

required boosting

binds cations!

CrCL> 70

Front 33

Antiherpes virus agents

Back 33

nucleoside analogs, antiviral (When incorporated into viral DNA chain, the chain is terminated

Front 34

Zovirax

notes

Back 34

Acyclovir

nucleoSIDE analogs

herpes is contagious

take with LOTS of WATER

Front 35

zovirax

tabs
caps
PO SUSP

TOPICAL cream or oint

Back 35

T: 400, 800
C: 200

SUSP: 200mg/5 mL

5%

Front 36

Valtrex (Valcyclovir)

Back 36

tabs: 500, 1000mg

Front 37

Famvir (Famciclovir)

Back 37

125, 250, 500mg

Front 38

Denavir (Penciclovir)

Back 38

TOPICAL CREAM

1%