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29 Cards in this Set
- Front
- Back
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what HIV type is more difficult to treat? what type of virus is HIV? Other than bodily fluids, how can HIV be transmitted? how long does it take until HIV antibodies are detected? |
type 2 RNA retrovirus pregnancy, birth, breastfeeding 4-8 weeks |
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How early can HIV antigens be detected after infection? how is HIV diagnosis confirmed? when should the otc hiv test, oraquick, be used after possible infection? |
2 weeks hiv immunoassay screening and supplemental confirmatory test both need to be positive 3 months post exposure |
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what is the most important indicator of ART response? what are the steps/life cycle of HIV infection? |
viral load 1 binding/attachment via CCR5/CXCR4 2 fusion 3 HIV RNA is converted to DS HIV DNA by reverse transcriptase 4 HIV dna is transported and integrated into host cell genome 5 transcription and translation into new hiv rna 6 assembly 7 budding and protease cleaves viral proteins into functional proteins |
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what percentage of adherence is required for successful ART treatment? side effect of all ART? what number and class of drugs should be used to treat infected pregnant women? |
95% diarrhea 2 NRTIs and a boosted PI or integrase inhibitor |
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how do the NRTIs work? Do NRTIs require renal dose adjustment? Do they have a lot of CYP interactions? what does the boxed warning for the NRTIs include? |
inhibit reverse transcriptase which blocks HIV viral RNA dependent DNA polymerase and causes chain termination yes none lactic acidosis and hepatomegaly with steatosis |
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what is the brand name for abacavir? brand name for "" plus lamivudine? brand name for "" plus dolutegravir? brand name for lamivudine alone ? |
ziagen epzicom Triumeq epivir |
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what drug can be used for both HBV and HIV and you must pay attention to the dose? what drug should this not be combined with? why? |
lamivudine emtricitabine, both are cytosine analogs |
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brand name for emtricitabine? brand name for "" plus tenofovir disoproxil fumarate? "" tenofovir alafenamide? |
emtriva Truvada Descovy |
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brand name for emtricitabine tenofovir and elvitegravir? "" elvitegravir and cobicistat? emtricitabine, efavirenz, tenofovir |
Stribild genvoya atripla |
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brand name for tenofovir? "" emtricitabine and rilpvirine what is in odefsey? |
viread complera tenofovir, rilpvirine, emtricitabine |
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when is the best time to take atripla? should you take it with food? what class is zidovudine? major side effects of zidovudine? what other NRTI should not be combined with this? why? |
empty stomach before bed NRTI hematologic toxicity, myopathy, macrocytic anemia stavudine, both are thymidine analogs |
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what drug should be used for a pregnant HIV mother in labor? are HIV suspensions/oral solutions usually refrigerated or not? major side effects of stavudine? |
IV zidovudine they are refrigerated peripheral neuropathy, lipoatrophy |
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what other NRTI can cause peripheral neuropathy? major side effect of didanosine ? |
didanosine adn stavudine pancreatitis |
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how do the NNRTIs work? Is this class usually first line? do you have to renally adjust the NNRTIs? As a class, what side effects are common? |
inhibit reverse transcriptase never nope rash and hepatotox |
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brand name for efavirenz? major side effects? what NNRTI requires a "lead in" 14 day period at a lower dose? what is the purpose of this? |
sustiva psyciatric and CNS effects, abnormal dreams nevirapine...decreases risk of rash and hepatotox |
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what specific CD4 count in women, should nevirapine be avoided? CD4 count in men? what is the brand name for rilpivrine? |
greater than 250 greater than 400 NNRTI, edurant |
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what is in complera? what drugs are contraindicated with rilpivirine ? how can efavirenz and nevirapine affect methadone? what other drug class can these two drugs decrease the effectiveness of ? |
rilpivirine, emtricitibine, tenofovir strong 3a4 inducers and PPIs can decrease levels and lead to withdrawal hormonal contraceptive levels |
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what is the suffix of all HIV protease inhibitors? are PI's ever used alone? what are the two booster drugs? Are the PI's renally adjusted? do the PI's affect the liver ? side effect of all PI's? |
navir they are always combined with a booster ritonavir and cobicistat no yes, hepatoxic, and are cyp inhibitors metabolic abnormalities |
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brand name of darunavir? brand for atazanavir? what are the major side effects of atazanavir? major drug interaction with atazanavir? |
prezista reyataz PR interval prolongation, nephrolithiasis and cholethiasis acid suppressive medications |
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what drugs have a potential sulfa allergy major side effect of indinavir? anything you can do to prevent it? what other drug has this side effect? what is unique about the indinavir solution? |
darunavir, fosamprenavir, tipranavir nephrolithasis, drink 48 oz of water atazanavir, drink water contains 42% alcohol |
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what NNRTI does not require boosting? major side effect/box warning of tipranavir? would PI's increase or decrease INR? how would ritonavir affect methadone? |
nelfinavir hepatitis and intracranial hemorrhage decrease, 2c9 induction, clotting, increase warfarin dose decreases levels from induction, watch withdrawal, same with nevirapine and efanvirenz |
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most statins are contraindicated with PI's, but which ones are preferred if you had to use them? what is the major difference between ritonavir and cobcicstat? what is unique about the ritonavir solution? |
rosuvastatin, atorvastatin both are boosters by inhibiting 3a4, but ritonavir itself is a PI contains 43% alcohol |
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what is the suffix of integrase inhibitors? what is the creatine cut off for stribild? genvoya? |
tegravir 70 ml/min 30 ml/min, integrase inhibitors dont require any other dose adjustments |
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brand name for dolutegravir? unique side effect? brand name for raltegravir? unique side effect? major drug interaction with all integrase inhibitors? |
tivicay increase in cpk, rhabdo, myopathy isentress increase in scr without affecting gfr cation containing medications, no issue with acid suppressants though |
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what test is required before you give maraviroc? what does this test determine? what do the results of the test need to show in order to endorse this therapy? how is the infusion inhibitor, enfuvirtide, given? main issue with this drug ? |
tropism test determines the type of coreceptor need ccr5 tropic disease, does not work with cxcr4 or both co receptors SC 98% of injection site reactions |
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what ART should be given without food? what syndrome can arise one the immune system recovers from use of ART? what can this cause? what class of drugs causes lipohypertrophy and buffalo hump? |
atripla, didanosine, indinavir, efavirenz, fosamprenavir immune reconsititution inflammatory syndrome, reaction of preexisting infections PI's |
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what drugs cause lipoatrophy? what drug is used as pre exposure prophylaxis? if doing PrEP, how often should you get assessed? |
stivudine and zidovudine truvada every 3 months |
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what drug combination is used for postexposure prophylaxis? how soon should you get the meds? how long is the treatment for? |
truvada+ raltegravir or dolutegravir or truvada with darunavir within 72 hours 4 weeks |
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what is the tenofovir poweder mixed with? side effects of rilpivirine |
not liquid, but soft foods insomnia, depression |
