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31 Cards in this Set

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Abacavir
NRTI: Ziagen
300mg bid, 600mg QD
SE-Hypersensitivity, Only NRTI with no renal adjustment
Didanosine
NRTI: Videx
>60kg 400mg QD,<60kg 250mg QD

TAKE ON EMPTY STOMACH
AE: Pancreatitis and peripheral Neuropathy
Emtricitabine
NRTI:Emtriva
200mg or 240 mg (24mL) Solution QD
AE: Hyperpigmentation (palms/feet)
Lamivudine
Epivir
300mg QD or 150 BID
Well tolerated
Stavudine
Zerit
>60kg: 40mg bid
<60kg: 30mg bid
AE:Peripheral neuropathy,lipoatrophy
Tenofovir
Nucleotide RTI: Viread
300mg QD
AE: nephrotoxicity, flatulence
Zidovudine
NRTI: Retrovir
300mg bid, 200mg tid
AE: anemia, myopaathy
Use in pregnant women and neonates, decr. vertical transmission
NRTIs
Inhibit reverse transcriptase enzyme by mimicking natural nucleotides.

Black Box warning for Lactic Acidosis

SE of fatigue,ha nausea
Take with or without food except didanosine
Delavirdine
NNRTIs: Rescriptor
Rarely used
Efavirenz
Sustiva
600mg QHS
AE: Vivid dreams, drowsiness
TAKE ON EMPTY STOMACH
false +ve canaboid test
-ve effect on lipid profile
Etravirine
NNRTI: Intelence
200mg BID
AE: Rash
TAKE WITH FOOD
-higher resistance
Ci with unboosted PIs
Nevirapine
NNRTI: Viramune
200mgQD *14days then 200 BID
AE: Rash
Hepatotoxicity ( do not use if cd4 >250 F and >400men)
ONLY ART initiated at lower dose
NNRTIs
Inhibit reverse transcriptase by binding directly to the enzyme.
CYP450 many drug interactions
Protease Inhibitors
Take with food to increase tolerability(Nelfinavir to increase absoption)

Increase ther risk of bleeding in pts with hemophilla

-Associated with long term metabolic effects (  triglycerides,  blood glucose, and fat redistribution (lipodystrophy))
-Inhibitors of CYP3A4 except tipranavir which is an inducer
-With PDE5 need to decr, dose and interval
- sulfa moiety in fosamprenavir, darunavir, and tipranavir be aware of sulfonamide allergy
Atzanavir
PI: Reyataz
400mg QD or
300mg w 100RTV QD
AE: Hyperbilirubinemia, Nephrolithiasis (kidney stones)

DI: antacids- 2hrs before or 1 hr after atzanavir, H2-blocker= simultaneously or <10hr after boosted atzanavir,
PPI+ not recommended in tx experienced pts. Max dose = 20mg qd of prilosec 12 hrs before /after
-Increase fluid intake to  risk of nephrolithiasis
Darunavir
Prezista
800mg + RTV100 QD pt naive only
600mg +RTV100 BID
Fosamprenavir
PI: Lexiva
1400mg bid or
1400mg + RTV 100-200 mg QD (Pt naive only)

700mg+ RTV100 BID
Indinavir
Crixivan
800mg +RTV 100-200 BID
AE: Hyperbilirubinemia ,
nephrolithiasis
Lopinavir/ritinovir
PI: Kaletra
200/50 or 100/25
2tabs bid or
4 tabs qd (pt naive only)
Nelfinavir
PI: Viracept
1250mg bid, 750 tid
ONlY PI that cannot be boosted with RTV
Ritinovir
PI:Norvir
100-200 mg with other PIs
AE: Gastrointestinal, lipid effects
-used to inhibit metabolism of other PIs(cyp3A4 inhibitor)
Saquinavir
Invirase
1000mg with 100mg RTV bid
Tipranavir
Aptivus
500mg with RTV200mg bid
CYP3A4 inducer therefore given with a higher dose of RTV
Maraviroc
CCR5:
Selzentry
150-600mg BID
AE: Rash, Cough fever, Hepatotoxicity

Testing for tropism assay required beforeinitiation
Enfuvirtide
Fusion Inhibitor
Fuzeon
90mg SC BID
AE: Injection site rxn

unused doses can be refrigerator (use within 24hrs)
Raltegravir
Integrase inhibitor
Isentress
400mg bid
AE: usually well tolerated, CPK elevation, nausea, HA

with Rifampin increase to 800mg BID
Zidovudine and Lamivudine
Combivir

300/150 mg BID
Zidovudine, Lamivudine, and abacavir
Trizivir

300/150/300 mg BID
Lamivudine and abacavir
Epzicom

300/600 mg QD
Tenofovir, emtricitabine, efavirenz
Atripla

300/200/600 QHS
Tenofovir, emtricitabine
Truvada

300/200 mg QD