Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
bacitracin
|
G+ toxic to kidney, given orally
|
|
|
Paul Ehrlich
|
father of chemotherapy looking for "magic bullet"
|
|
|
Bacterial plasma membrane disruptors
|
polymoxin which interacts with the phospholipids in the membrane
|
|
|
E-Test
|
combines agar difussion and MIC Advantages - more flexible can be used on wider variety of microbes & growth conditions Disadvantages - very expensive
|
|
|
methicilin oxacillin
|
resistant to B-lactomase
|
|
|
Alexander Fleming
|
discover penicillin 1st antibiotic
|
|
|
B-lactam antibiotics
|
penicillin and semi-synthetic penicillins
|
|
|
problems with overuse of antibiotics
|
toxicity, allergic reactions, and destruction of normal flora
|
|
|
When selecting an antibiotic you must make sure that the organism does not
|
produce enzymes that will destroy the drug, prevent entry of the drug, or cause mutation or chromosome change
|
|
|
Kirby-Bauer test
|
agar difussion test -- swab plate, add antibiotics, incubate
|
|
|
eflux pumps
|
im plasma membrane pump out the drug
|
|
|
MIC -- Minimum Inhibitory Concentration
|
lowest concentration of drug that will inhibit growth
|
|
|
natural penicillin
|
G & V (synthesized by mold), has a narrow spectrum, G+, B-lactamase and acid sensitive
|
|
|
MLC -- Mininum Lethal Concentration
|
Lowest concentration of drug to kill organism
|
|
|
cephalosporim
|
semi-synthetics 2nd, 3rd, 4th, generations
|
|
|
mutation on chromosome
|
change antibiotic target site so that it can no longer bind
|
|
|
semi-synthetic penicillins
|
synthesized by mold then chemically altered in lab (amoxicillin)
|
|
|
vangomycin (glycopeptide)
|
given by IV effective for G+ only, used as a last resort
|
