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16 Cards in this Set
- Front
- Back
Blood- a type of CT
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- cells with greater volume of ECM (the fluid is the ECM)
- Function: transport, homeostasis (balance of fluids), immune response |
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Blood Composition
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Cells:
- Erythrocytes (red blood cells) - Leukocytes (white blood cells) - Platelets (thrombocytes) Extracellular Matrix: plasma Hematocrit- how you measure the amount of RBC in your body |
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Plasma
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- liquid extracellular matrix
- Composition: water (91-92%) proteins (7-8%)- including: Albumin (maintains osmotic pressure (responsible for exerting the concentration gradient btwn blood and ECM), 50% of the proteins) Globulins (family of proteins ex: immunoglobulins- antibodies) Fibrinogen (involved in blood clotting process- it is transformed into fibrin) Other solutes (1-2%) Interstitial fluid of CT derived from blood plasma |
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Erythrocyte
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- anucleate, biconcave disk
- function: oxygen delivery and CO2 removal - flexible, cytoskeleton-dependent shape - the unique cell shape helps with gas exchange - distinct cytoskeleton maintains shape (maintains shape by membrane proteins) - RBC lifespan = 120 days |
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Hemoglobin
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- a protein with 4 polypeptide chains (alpha and beta chains) with Heme groups
- Iron in Heme group binds oxygen - Main type of Hemoglobin: HbA (90-95% made of this; 2 alpha and two beta chains) |
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Diseases associated with Hemoglobin
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- Anemia- low RBC count
-Hypochromic anemia (low amounts of hemoglobin) -Polycythemia (erythrocytosis)- higher concentration of RBC; can happen in high altitudes) - Sickle Cell Anemia- point mutation in one of the beta chains; aren't flexible so they tend to clot and also the cells don't live as long. Carriers of Sickle Cell Anemia do have benefits against malaria) |
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ABO Blood Group:
Blood Types: - A - B - AB - O |
-A: Erythrocyte surface antigen= A antigen; Serum antibody= anti-B
-B: Erythrocyte surface antigen= B antigen; Serum antibody= Anti-A -AB: Erythrocyte Surface antigen= A & B antigen; Serum antibody= no antibody (universal acceptor) -O: Erythrocyte surface antigen= no antigen; Serum antibody= anti-A and B (universal donor) Ex: A types have antibodies that are anti-B |
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Rh+
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another antigen on the surface of blood (most people are +). Women who are Rh- and have a baby who is Rh-, if during the delivery or development the baby's blood could get back to mom and she makes antibodies. The problem: if the 2nd baby is Rh+, the antibodies could be harmful to the baby (erythroblastosis fetalis)
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Neutrophils
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- 10-12 um; most numerous WBCs
- multilobed nucleus (2-5) bar body in females - neutrophils contain 3 granule types: 1. Specific granules (small)- contain various enzymes 2. Azurophiles (target bacteria) 3. Tertiary granules (aid in migration) - Bacteria Target |
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Neutrophil Migration
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- travel along blood to infection sites and target pathogens
- they have surface adhesion molecules (selectin- on the surface of the circulating neutrophil, interacts with receptors on the surface of the endothelial cells) |
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Eosinophil
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- 2-4% of leukocytes
- bilobed nucleus - two granules: specific granules (contain a crystalloid body) and azurophilic granules - worm killers- kill parasitic worms in the heart - eosinophils are associated with allergic rxns, parasitic infections, and chronic inflammation |
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Basophil
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-associated with lots of granules
- rare - irregularly lobed nucleus - two granules: specific granules (heparin containing granules- heparin is an anticoagulant); azurophilic granules - supplement mast cells (basophils act like mast cells in helping take up antigens) |
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Lymphocyte
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- 2 size groups
small (6-8 um) med/lg (up to 18 um) - small most abundant: nucleus often indented ring shaped cytoplasm - lymphocytes are the main functional cells of the immune system |
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Monocyte
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- 12-20 um (largest of the WBCs)
- oval nucleus- horse-shoe or kidney shaped - numerous microvilli - they transform macrophages in CT, which function as antigen-presenting cells in the immune system - monocytes are the precursors of the cells of the mononuclear phagocytotic system |
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Platelets (Thrombocytes)
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- fragments of cells- not actually cells
- nonnucleated disklike cell fragments (megakaryocytes in bone marrow are where platelets are derived from) - open canalicular system - marginal microtubule bundles - function in blood clotting - hemophilia (can't clot blood- more common in men) - megakaryocytes- have karyokinesis but no cytokinesis (can get up to 64n- polyploidy) - no nucleus in platelets |
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Hematopoiesis
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- the formation of blood cells
- start with pluripotent cell--> lymphoid or myeloid cells - Lymphoids: form lymphocytes and plasma cells - Myeloids: form RBC, monocytes, eosinophils, basophils, neutrophils, megakaryocytes - all of this occurs in the bone marrow |