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6 Cards in this Set

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Role of:
-Myosin
-Actin
-Tropomyosin
-Troponin
-Calcium
-ATP
.
Role of:


-Myosin
myosin molecules are composed of a head, neck, and tail domain.

The head domain binds the filamentous actin, and uses ATP hydrolysis to generate force and to "walk" along the filament towards the barbed (+) end
Role of:

-Actin
myosin molecules are composed of a head, neck, and tail domain.

The head domain binds the filamentous actin, and uses ATP hydrolysis to generate force and to "walk" along the filament towards the barbed (+) end
Role of:

-Tropomyosin
Tropomyosin wrap around actin like a slinky. It functions to block myosin from attaching to actin
Normally in resting phase, when the muscle is relaxed, the troponin complex is blocking the myosin-binding site.
Role of:


-Troponin
Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. In a relaxed muscle, tropomyosin blocks the attachment site for the myosin crossbridge, thus preventing contraction. When the muscle cell is stimulated to contract by an action potential, calcium channels open in the sarcoplasmic reticulum and release calcium into the sarcoplasm. Some of this calcium attaches to troponin, causing a conformational change that moves tropomyosin out of the way so that the cross bridges can attach to actin and produce muscle contraction.
Role of:

-Calcium
Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. In a relaxed muscle, tropomyosin blocks the attachment site for the myosin crossbridge, thus preventing contraction. When the muscle cell is stimulated to contract by an action potential, calcium channels open in the sarcoplasmic reticulum and release calcium into the sarcoplasm. Some of this calcium attaches to troponin, causing a conformational change that moves tropomyosin out of the way so that the cross bridges can attach to actin and produce muscle contraction.