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62 Cards in this Set
- Front
- Back
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Lymph Node
Basic Division |
Cortex with lymph nodules
Medulla with cells and lymph sinuses |
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Lymph Node
Lymph Nodules |
Yes, in cortex!
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Lymph Node
Cords and Sinuses |
Yes, in medulla!
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Lymph Node
Basic Division |
Cortex with lymph nodules
Medulla with cells and lymph sinuses |
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Lymph node
Framework |
Reticular cells and fibers
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Lymph Node
Lymph Nodules |
Yes, in cortex!
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Lymphatic vessels
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Afferent and Efferent
Afferent-> subcapsular->trabecular sinus->medullary sinus->efferent |
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Lymph Node
Cords and Sinuses |
Yes, in medulla!
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Lymph node
Framework |
Reticular cells and fibers
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Lymphatic vessels
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Afferent and Efferent
Afferent-> subcapsular->trabecular sinus->medullary sinus->efferent |
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Lymph node
T-lymphocytes |
Inner or paracortex
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Lymph node
B-lymphocytes |
Lymph nodules in cortex
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Lymph node
Plasma cells |
cords in medulla
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Lymph node
Exposure to antigens |
in lymph
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Lymph node
Other features |
Subcapsular sinus
High-endothelial venules (HEV) for recirculation of lymphocytes from blood into lymph |
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Lymph node
FUNCTIONS |
Filters LYMPH
- trap debris and antigens in lymph (macrophages and other APC's) - T-cell activation, proliferation and release - B-cell activation, proliferation and differentiation into plasma cells that release antibodies into lymph |
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Spleen
Basic Divisions |
Red pulp with cells and blood sinusoids
White pulp with lymph tissue around arterioles |
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Spleen
Lymph nodules |
Yes (in white pulp)
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Spleen
Cords and sinuses |
Yes
- blood (venous) sinusoids in red pulp |
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Spleen
Framework |
Reticular cells and fibers
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Spleen
Lymphatic vessels |
Efferent only
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Spleen
T-lymphocytes |
Periarterial lymphatic sheath (PALS) in white pulp
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Spleen
B- lymphocytes |
Lymph nodules in white pulp
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Spleen
Plasma cells |
Cords in red pulp
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Spleen
Exposure to antigens |
-in blood
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Spleen
Other features |
- Lymphoid cells associated with arterioles (white pulp)
- Capillaries dump blood into red pulp tissue where it percolates INTO venous sinusoids |
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Spleen
Functions |
Filters BLOOD
- trap debris and antigens in blood (macrophages and other APC's) - T-cell activation, proliferation and release - B-cell activation, proliferation and differentiation into plasma cells that release antibodies into blood - breakdown, removal of damaged or old RBCs |
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Thymus
Basic divisions |
Cortex and medulla (divided into lobules)
1. Cortex (dark) 2. Medulla (light) with Hassalls corpuscles |
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Thymus
Lymph nodules |
NO lymph nodules
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Thymus
Cords and sinuses |
NO cords or sinuses
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Thymus
Framework |
Epithelial cells (endoderm) linked by desmosomes and tight junctions
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Thymus
Lymphatic vessels |
Efferent only
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Thymus
T-lymphocytes |
Cortex and medulla
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Thymus
B- lymphocytes |
No
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Thymus
Plasma cells |
No
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Thymus
Exposure to antigens |
Secluded by blood- thymus barrier in the cortex
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Thymus
Other features |
Hassall's corpuscles in medulla formed by epithelial cells
-infiltrated with adipose cells with age |
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Thymus
Functions |
Maturation and education of T-lymphocytes to recognize "self" secluded from antigens
Epithelial cells are part of blood-thymus barrier, and produce thymic hormones |
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What are primary lymphoid organs?
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Thymus and bone marrow
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What are secondary lymphoid organs?
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Diffuse infiltrate
lymph nodules lymph nodes tonsils spleen |
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Main components of lymphatic organs
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Parenchyma- lymphoid cells
Stroma- connective tissue cells Vasculature- lymphatic vessels, blood vessels, sinusoids |
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What do lymphocytes do?
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They move through tissues and circulate through blood and lymph vessels gaining exposure to encountered antigens.
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Where do T-cells come from?
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THYMUS
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What do T-cells do?
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Have T-cell receptors
ie CD 2,4,8 etc. CELL MEDIATED IMMUNITY They seek out antigen directly and contact it to cause destruction (ie tumor cell lysis) Produce cytokinins (interleukins) |
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Where do B-cells come from?
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Bone marrow, Bursa of fabricius
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What do B-cells do?
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B-cell surface markers: CD19, 20, 22
HUMORAL IMMUNITY Production of antibodies DIfferentiation into plasma cells Contact with antigen not required for destruction of antigen. |
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What is a TPC?
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TPC= third population cell
lack T-cell or B-cell surface markers Include natural killer cells and antibody dependent cellular cytotoxicity cells (ADCCs) |
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Where do macrophages come from?
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Macrophages differentiate from monocytes in connective tissue.
Ex: Kupffer cells in liver, dust cells in lungs, mesangial cells in kidney |
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What is an antigen presenting cell (APC)?
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Antigen presenting cells have extended dentritic (long, thing) processes with high concentrations of MHCs, major histocompatibility molecules.
They capture and process antigens and help initiate immune response by presenting them to T-cells Ex: epidermal Langerhans cells, dendritic cells in B-cell areas called follicular cells or interdigitating dendritic cells in T-cell areas. In lymph circulation they are "veiled" cells. |
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Epithelium of palatine and lingual tonsils
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Stratified squamous epithelium
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Epithelium of pharyngeal tonsils
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pseudostratified ciliated epithelium
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Stroma epithelial cells of thymus are derived from...
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Endoderm
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Esophagus
epithelium |
stratified squamous nonkeratinized
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Esophagus
lamina propria |
Esophageal cardiac glands
-mucous cells |
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Esophagus
muscularis mucosa |
present
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Esophagus
submucosa |
Esophageal glands proper
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Esophagus
muscularis externae |
skeletal (upper)
mixed (middle) smooth (lower): inner circular and outer longitudinal |
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Cardiac stomach
Epithelium |
Simple columnar
(secretes mucous) |
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Cardiac stomach
Lamina propria |
Cardiac glands
-mucous cells -enteroendocrine |
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Cardiac stomach
muscularis mucosa |
present
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Cardiac stomach
submucosa |
no glands
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cardiac stomach
muscularis externae |
Smooth muscle
oblique, circular and longitudinal |
