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29 Cards in this Set

  • Front
  • Back
Total volume of blood in normal adult
6 L - 7-8 % of total body weight
Functions of blood
-Transport of nutrients and oxygen to cells
-Transport of wastes and CO2 from cells
-Delivery of hormones to and from cells
-Homeostasis via buffers
-Immune system
Hematocrit
Volume of packed RBC's in sample of blood
Normal hematocrit in males and females
Males - 39-50 %
Females - 35-45%
Leukocytes and platelets make _ % of blood
1
90 % of plasma is _
Water
Main protein of plasma
Albumin
Largest plasma protein is _ , its made in _
Fibrinogen,liver
RBC's have _ staining
Eosinophilic
Describe nucleus and organelles of RBC
Anucleate biconcave disc without organelles
Life span RBC
120 days
Cell membrane of RBC is _
Lipid blayer
Types of proteins in cell membrane of RBC
Integral - most, glycophorins and band 3 proteins - anchoring for cytoskeletal proteins
Peripheral - 2D hexagonal lattice that laminates inner layer of membrane - spectrin, actin, band 4.1, 4.9, adducin, tropomyosin
What gives eosinophilic staining to RBC's
Hemoglobin
Structure of Hb
four polypeptide chains of globin alpha beta gamma and delta connected to Fe containing heme
2 groups of leukocytes
Granular
Agranular
Granulocytes are _
Neutrophils
Eosinophils
Basophils
Agranulocytes are
Lymphocytes
Monocytes
Azurophilic granules are generally_
Lysosomes
Most numerous WBC
Neutrophils
What gives name to neutrophils
Lack of characteristic staining
Another name for neutrophils
Polymorphonuclear cells
Describe nucleus of neutrophil
Multilobed
Heterochromatin - periphery
Euchromatin - center
Barr body in woman - drumstick shaped appendage on one of nuclear lobes
3 types of granules in neutrophils
Specific granules - secondary, twice as numerous as azurophilic, very small, contain enzymes type IV collagenase, phosphatase, activators of complement system
Azurophilic - primary, less numerous, lysosomes, contain myeloperoxidase which generates bactericidal hypochlorite, has defensins that also kill bacteria
Tertiary granules - one type contains phosphatases, other type metalloproteinases
Important property of neutrophils that distinguishes them is _
their motility
Sickle cell disease
Single point mutation in the gene that encodes beta globulin chain of HbA. Valine is substituted for glutamic acid in position 6. Cells become rigid and pile up in small capillaries, can lead to stroke, pain, etc
Describe neutrophil phagocytosis
1. Recognition by Fc receptor
2. Extension of pseudopods
3. Engulfment of foreign body
4. Formation of phagosome
5. Formation of phagolysosome
6. Digestion
7. Storage in residual body or exocytosis
Nucleus of eosinophil
Bilobed
Heterochromatin in periphery, euchromatin in center
Specific granules in eosinophils contain 2 main parts -
crystalloid body and matrix