Histology 6- Integument

Front 1

Stratum basale (Stratum germinativum):

what shape, how many layers, what IDing features, what type of fillaments, what type of connections?

Back 1

Single layer of columnar to cuboidal cells
Numerous mitotic figures in layer.
Cells contain numerous intermediate filaments
Desmosomes on lateral and upper surface. – velcro
Hemidesmosomes bind cells to basement membrane.

Front 2

Stataum Basale cancer

Back 2

They usually appear as a round area of thickened skin that does not change color or cause pain or itching.
Very slowly, the lesion spreads and develops a raised edge, which may be translucent and smooth. Eventually, the center becomes hollowed and covered with a thin skin, which can become sore and open.
infiltrates the dermis

Front 3

Histologically, Basal Cell Carcinoma is characterized by:

Back 3

clusters of darkly staining basal cells with a palisade (stake-like) arrangement of nuclei at the periphery of the clusters.

Front 4

Stratum spinosum
shape, fillaments, connections

Back 4

Cells are cuboidal to polygonal
Cell processes filled with intermediate filaments that terminate with desmosomes
Some mitotic figures may also present in this layer.

Front 5

Squamous cell cancer involves cancerous changes to the cells of the _____________.

Back 5

middle portion of the epidermal skin layer

Front 6

_________is a malignant tumor, and is more aggressive than basal cell cancer, but still may be relatively slow-growing.

Back 6

Squamous cell cancer

Front 7

Squamous Cell cancer is (more/less) likely than basal cell cancer to spread (metastasize) to other locations, including internal organs.

Back 7

More Likely

Front 8

Stratum granulosum
layers, shape, key function, cytoplasmic contents

Back 8

3-5 layers - flattened polygonal cells.
Cytoplasm has basophilic keratohyaline granules.
Glycolipid (acylglucoceramide) material serves a penetration barrier to foreign materials and maintains hydration of the body.

Front 9

Stratum corneum

Back 9

Most superficial layer of flattened nonnucleated cells filled with keratin.
Cells are continuously being sloughed off
Keratinized means generally 4+ layers (thick skin)

Front 10

Langerhans’ cells

Back 10

Star shaped cells found in a pale halo - mainly in the Stratum spinosum (Can migrate out of epidermis to lymph nodes)
Bone marrow derived - monocytes.
Function as antigen-presenting cells

Front 11

Langerhans cells are _________ in the 2nd layer of skin

Back 11

antigen presenting cells

Front 12

Dermis
what type of CT?
superficial, deep

Back 12

Most superficial layer (papillary layer) of the dermis is usually loose connective tissue. Deeper layer (reticular layer) is usually dense irregular connective tissue

Front 13

what type of cells are present in the dermis?

Back 13

Fibroblasts, mast cells, & macrophages may be present.