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222 Cards in this Set

  • Front
  • Back

skeletal muscle

bundles of long multinucleated cells with cross-striations; contraction is quick, forceful, voluntary control

cardiac muscle

cross-striations, elongated and branched cells bound at intercalated discs; contraction involuntary, vigorous, rhythmic

intercalated discs

dark-staining transverse lines that cross the chains of cardiac cells at irregular intervals where the cells join, contain many junctional complexes

smooth muscle

collections of fusiform cells with no striations; contractions slow and involuntary

sarcoplasm

cytoplasm of muscle cells

sarcoplasmic reticulum

smooth endoplasmic reticulum of muscle cells, specialized for Ca ion sequestration

sarcolemma

muscle cell membrane and external lamina

muscle fibers

long, cylindrical multinucleated cells with diameters of 10 to 100 um

satellite cells

reserve muscle progenitor cells that sit adjacent to most differentiated skeletal muscle fibers

epimysium

external sheath of dense CT that surrounds the entire muscle- brings large nerves, blood vessels, and lymphatics

perimysium

thin CT layer that surrounds each fascicle

fascicle

bundle of muscle fibers- functional unit in which fibers work together

endomysium

thin layer of reticular fibers and scattered fibroblasts that surrounds external lamina of individual muscle fibers- brings nerve fibers and capillaries

myotendinous junction

where epimysium is continuous with the dense regular CT of a tendon

A bands

anisotropic/birefringent/dark in EM, consist of thick filaments and overlapping thin filaments,

I bands

isotropic/light in EM, consist of the portions of the thin filaments that do not overlap the thick filaments, have titin and nebulin

Z disc

dark band that bisects I band

sarcomere

repetitive functional subunit of the contractile apparatus- Z disc to Z disc

myofribrils

cylindrical filament bundles in the sarcoplasm, consisting of an end-to-end arrangement of sarcomeres

myofilaments

thick and thin filaments in the sarcoplasm composed of myosin and F-actin

myosin

large complex with two identical heavy chains and two pairs of light chains

actomyosin ATPase activity

the function of myosin when it binds ATP and catalyzes energy release

alpha-actinin

actin binding protein that anchors actin filaments on the Z disc

tropomyosin

long coil of two polypeptide chains located in the groove between the two twisted actin strands

troponin

complex of three subunits: TnT- attaches to tropomyosin, TnC- binds Calcium ions, TnI- regulates actin-myosin interactions

titin

largest protein in the body, has scaffolding and elastic properties, supports the thick myofilaments and connects them to the Z disc

nebulin

large accessory protein that binds each thin myofilament laterally, helps anchor them to alpha-actinin, and specifies length of the actin polymers during myogenesis

H zone

lighter staining zone in A band where only rodlike portions of myosin lie and there are no thin filaments, bisected by M line

M line

line that bisects the H zone and contains a myomesin and creatine kinase

myomesin

myosin-binding protein found in M line, holds thick filaments in place

creatine kinase

enzyme that catalyzes transfer of phosphate groups from phosphocreatine to ADP to supply ATP for muscle contraction, found in M line

transverse/T tubules

long invaginations of cell membrane that encircle every myofibril near the aligned A and I band boundaries and cause uniform contraction of all myofibrils

terminal cisterns

expanded cisterns on either side of the t tubule that store concentrated calcium ions

triad

t tubule and two terminal cisterns

rigor mortis

rigidity of skeletal muscles after death when mitochondrial activity stops, removing ATP and making actin-myosin crossbridges stable

motor end plate

synaptic structure where the axonal branch forms a dilated termination in a trough on the muscle cell surface

acetylcholine

neurotransmitter located in synaptic vesicles

synaptic cleft

space between the axon and the muscle

junctional folds

folds in the sarcolemma that add postsynaptic surface area and transmembrane acetylcholine receptors

acetylcholine receptor

receptor on the sarcolemma that binds acetylcholine and has a nonselective cation channel that allows the influx of sodium ions, depolarizes the sarcolemma, and produces the muscle action potential

acetylcholinesterase

extracellular enzyme that removes free acetylcholine after the muscle contraction

motor unit

an axon and all the muscle fibers in contact with its branches

muscle spindles

stretch detectors in muscle fascicles, encapsulated by modified perimysium, has concentric layers of flattened cells, interstitial fluid, and intrafusal fibers

intrafusal fibers

thin muscle fibers in muscle spindles with nuclei

Golgi tendon organs

smaller encapsulated structures that enclose sensory axons that penetrate myotendinous junctions, detecting changes in tendon tensions

myoglobin

cytoplasmic protein abundant in slow, oxidative muscle fibers that contains iron and stores oxygen molecules

caveolae

short membrane invaginations of smooth muscle cells

calmodulin

alternative to troponin in smooth muscle cells

myosin light-chain kinase

Calcium ion-sensitive kinase involved in contractile mechanism

dense bodies

bodies associated with the sarcolemma and cytoplasm of smooth muscle cells that have alpha-actinin and are functionally similar to Z discs in skeletal muscle

neurons

nerve cells, which have numerous long processes

glial cells

cells that support and protect neurons, have short processes, and participate in neural activities, neural nutrition, and the defense of CNS cells

central nervous system

division of the nervous system consisting of the brain and spinal cord

peripheral nervous system

division of the nervous system consisting of the cranial, spinal, and peripheral nerves that conduct impulses to and from the CNS and ganglia outside the CNS

stimuli

environmental changes that neurons respond to

excitable

cells that rapidly change their electrical potential in response to stimuli

membrane depolarization

reversal of the ionic gradient of the plasma membrane

action potential/nerve impulse

propagation of the depolarization across the entire plasma membrane

neural plate

thickened ectoderm on the mid-dorsal side of the embryo, epithelial

neural tube

when neural plate bends and grows together medially

neural crest

large population of cells that will differentiate into cells of the PNS and other things

perikaryon/cell body

cell body of the neuron, which contains the nucleus and most organelles

dendrites

numerous elongated processes extending from the perikaryon and specialized to receive stimuli from other neurons at synapses, branch a lot

axon

single long process that ends at a synapse, specialized to generate and conduct nerve impulses

multipolar

one axon and two or more dendrites

bipolar

one dendrite and one axon

unipolar/pseudounipolar

one process that bifurcates near perikaryon, longer branch going to the PNS and other to the CNS

anaxonic

many dendrites but no true axon- regulate electrical changes of adjacent neurons

sensory/afferent neurons

receive stimuli from receptors throughout the body

motor/efferent neurons

send impulses to effector organs

somatic

nerves under voluntary control, innervate skeletal muscle

autonomic

nerves under involuntary control, control activities of glands, cardiac muscle, and smooth muscle

interneurons

99% of neurons, establish relationships among other neurons and form functional networks called circuits

gray matter

part of CNS in spinal cord where neuronal perikarya concentrated

white matter

part of CNS in spinal cord where axons concentrated

nerves

bundles of axons in the PNS

neurofilaments

intermediate filaments abundant in nerve cells

Nissl substance

clumps of basophilic material that consist of concentrated RER and polysomes

dendritic spines

short blunt structures projecting at points along dendrites that initially process synapses

axon hillock

pyramid-shaped region of the perikaryon where axon originates

axolemma

plasma membrane of an axon

axoplasm

cytoplasm of the axon that contains mitochondria, microtubules, neurofilaments, and SER but no RER or polyribosomes

terminal arborization

distal end of the axon that branches

collaterals

branches of interneuron and some motor neuron axons

terminal bouton

dilation of each branch of an axon that contacts another axon or non-nerve cell at a synapse

anterograde transport (neuron)

from perikaryon to synaptic terminal through axon, mediated by kinesin

retrograde transport (neuron)

from synaptic terminal to perikaryon, not as common, mediated by dyenin

voltage-gated Na+ and K+ channels

produce waves of membrane depolarization by opening and closing to allow the ion content of the cell to change

resting potential

little Na+ in cell compared to ECF and lots of K+ in cell

presynaptic cell

cell that gives off an electric signal (nerve impulse)

postsynaptic cell

cell affected by impulse/synapse- receives chemical signal

neurotransmitters

small molecules that bind specific receptor proteins to open or close ion channels

synaptic vesicles

vesicles that carry neurotransmitter released by exocytosis

postsynaptic cell membrane

has receptors for transmitter and ion channels

excitatory synapses

cause Na+ channels to open, resulting in depolarization

axosomatic

synapse between axon and cell body

axodendritic

synapse between axon and dendrite

axoaxonic

synapse between axon and axon

glial cells

cells that support neuronal survival and activities, develop from progenitor cells in the embryonic neural plate

neuropil

cellular processes of neurons and glial cells that make up a fibrous intercellular network

oligodendrocytes

glial cells that produce the myelin sheaths around axons, in white matter

astrocytes

glial cells that have a large umber of radiating processes, are in the CNS

fibrous astrocytes

astrocytes with few, long processes- in white matter

protoplasmic astrocytes

many shorter, branched processes, in the gray matter

glial fibrillary acid protein

protein that makes up intermediate fibers of astrocyte processes, common source of brain tumors

inhibitory synapse

opens Cl- or other anion channels to hyperpolarize cell membrane

perivascular feet

expanded ends of astrocyte processes that cover capillary endothelial cells

glial limiting membrane

barrier layer that lines the meninges, formed from expanded processes of astrocytes

ependymal cells

columnar or cuboidal glial cells that line the ventricles of the brain and the central canal of the spinal cord-move and absorb CSF

microglia

small glial cells with short irregular processes that secrete immunoregulatory cytokines and act as the immune defense in the CNS

Schwann cells

glial cells in PNS that myelinate axons and act as support

satellite cells of ganglia

glial cells in the PNS that form an intimate covering layer over the large neuronal cell bodies in the ganglia of PNS

tract


groups of myelinated axons in white matter

white matter

myelinated axons and oligodendrocytes, very few neuronal bodies, some astrocytes and microglia

gray matter

neuronal cell bodies, dendrites, unmyelinated parts of axons, where synapses occur

cerebellar cortex

part of brain that coordinates muscular activity throughout the body, and has three layers: outer molecular, Purkinje, inner granular

cerebral cortex

composed of six layers, integrates sensory info and initiates voluntary motor responses

pyramidal neurons

efferent neurons that comprise a layer in the cerebral cortex

molecular layer

outer layer of cerebellar cortex

Purkinje cells

large neurons that compose the central layer of the cerebellar cortex

granule layer

inner layer of the cerebellar cortex

central canal

opening in the spinal cord that develops from the lumen of the embryonic neural tube, continuous with ventricles, contains CSF, lined with ependymal cells

anterior horns

formed from gray matter, motor neurons

posterior horns

gray matter, sensory fibers

meninges

membranes of connective tissue between bones and nervous tissue: dura mater, arachnoid mater, pia mater

dura mater

thick external mater, dense, fibroelastic CT continuous with the periosteum of the skull

subdural space

space that separates the arachnoid mater from the dura mater

arachnoid mater

middle mater with 2 layers: sheet of CT and a system of loosely arranged trabeculae composed of collagen and fibroblasts

subarachnoid space

cavity surrounding trabeculae filled with CSF that communicates with ventricles of the brain

arachnoid villi

CSF filled protrusions of the arachnoid into the venous sinuses that are covered by vascular endothelial cells

pia mater

innermost mater that consists of flattened, mesenchymally derived cells

perivascular spaces

spaces covered by pia mater that blood vessels penetrate

blood-brain barrier

functional barrier that allows tight control over what passes from blood to CNS tissue, consists of capillary endothelium sealed with occluding junctions

limiting layer of perivascular astrocytic feet

completely envelopes the basal lamina of the capillaries in CNS regions- regulates passage of ions and molecules from blood to brain

choroid plexus

highly specialized tissue with elaborate folds and many villi in the ventricles that removes water from blood and makes CSF

CSF

clear fluid, contains Na+, K+ and Cl-, and a few lymphocytes- fills the ventricles and subarachnoid space to provide ions for neuronal activity and avoid physical shocks

chromatolysis

onset of regeneration: perikaryon swells slightly, Nissl substance diminishes, nucleus peripheral, etc.

neurotrophins

growth factors produced by neurons and glial cells

autonomic ganglia

control activity of smooth muscle, small bulbous dilations in autonomic nerves, layer of satellite cells

intramural ganglia

ganglia in the wall of the digestive tract

sensory ganglia

ganglia that receive afferent impulses, have large neuronal bodies with satellite cells and a CT capsule

epineurium

dense, irregular fibrous coat of entire nerves

perineurium

CT layer around nerve fascicles that contain flat fibrocytes joined by tight junctions

fascicles

bundles of axons with Schwann cells and endoneurium

endoneurium

reticular fibers, scattered fibroblasts, and capillaries that surround one Schwann cell

nerve

bundle of nerve fibers

unmyelinated fibers

axons enveloped in a simple fold of Schwann cell

internodal segment

length of an axon ensheathed by one Schwann cell

nerve fibers

analagous to tracts in CNS, axons enclosed in sheaths of Schwann cells

myelin sheath

layers of Schwann cell membrane fused together around an axon

major dense lines

fused, protein-rich cytoplasmic surfaces of the Schwann cell membrane

myelin cleft

separations in cytoplasmic surfaces to allow cytoplasm to move

nodes of Ranvier/nodal gaps

gaps between adjacent Schwann cells on a single axon

cardiovascular system

consists of heart, arteries, veins, arterioles, venules, and capillaries- circulates blood through body

arteries

vessels that carry blood to the tissues from the heart

capillaries

the smallest vessels that are the sites of O2, CO2, nutrient, and waste exchange between blood and tissues

microvasculature

network of capillaries, arterioles, and venules that anastomose

veins

vessels that carry blood from tissue to heart

pulmonary circulation

division of the circulatory system where blood is oxygenated in the lungs

systemic circulation

division of the circulatory system where blood brings nutrients and removes waste in tissues throughout the body

lymphatic vascular system

system that returns fluid from tissue spaces back to the heart

lymphatic capillaries

thin-walled, closed-ended tubules carrying lymph

endothelium

single layer of squamous epithelium that lines all components of the blood and lymphatic systems- selectively permeable

ventricles

chambers of heart that pump blood to systemic and pulmonary circulation

atria

chambers of the heart that receive blood from the body and pulmonary veins

endocardium

inner layer of heart wall- consists of thin endothelial layer with CT, a middle myoelastic layer of smooth muscle and connective tissue, and a deep layer of connective tissue

subendocardial layer

deep CT layer of endocardium that merges with the myocardium

myocardium

thickest layer of heart wall that consists of cardiac muscle surrounding heart, thicker around ventricles

epicardium

simple squamous mesothelium with loose CT, same as visceral layer of the pericardium

visceral layer of pericardium

membrane surrounding heart, known as epicardium

parietal layer of pericardium

outer layer of membrane surrounding heart

cardiac skeleton

dense irregular fibrous connective tissue that anchors and supports heart valves, provides points for insertion of cardiac muscle, and helps coordinates heartbeats

conducting system of the heart/subendocardial conducting network

generates and propagates waves of depolarization that go to myocardium- heartbeat

sinoatrial node

node in right atria of specialized cardiac muscle cells that creates initial impulse

atrioventricular node

in floor of right atrium, spreads depolarization

Atrioventricular bundle

takes impulse from AV node to subendocardial conducting network

Purkinje fibers

myofibers of subendocardial conducting network, pale staining, mingle with contractile muscle fibers, and cause contraction

vasa vasorum

blood vessels within the tunica adventitia in larger vessels

tunica adventitia

outer layer of vessels made up of collagen I and elastic fibers

tunica media

middle layer of vessel walls made up of smooth muscles, controls blood pressure, has elastic, reticular fibers, and proteoglycans

internal elastic lamina

limiting layer of tunica intima made of elastic

tunica intima

endothelium and loose CT subendothelial layer- inner layer of vascular wall

angiopoietins

growth factors that stimulate endothelial cells to attract smooth muscle fibers

angiogenesis

process of sprouting capillaries and vessels from existing ones

vasculogenesis

creation of vasculature from embryonic mesenchyme

endothelium

specialized epithelium that acts as a semipermeable barrier between blood plasma and interstitial tissue fluid

nonthrombogenic surface

endothelium- surface where blood will not clot

P-selectin

secreted to activate white blood cells in time of injury

interleukins

secreted by endothelial cells, affect the activity of local white blood cells during inflammation

elastic/conducting arteries

aorta, pulmonary artery, and large branches

systole

ventricular contraction, causes blood to move forcefully through arteries

diastole

ventricular relaxation, elastin passively rebounds in elastic arteries

carotid sinuses

slight dilations of the internal carotid arteries- act as baroreceptors

baroreceptors

monitor arterial blood pressure

chemoreceptors

monitor blood levels of CO2 and O2 and hydrogen ion concentrations

carotid bodies and aortic bodies

sites for chemoreceptors in the internal carotid arteries and the aortic arch

paraganglia

carotid bodies and aortic bodies that are parts of the autonomic nervous system and have rich capillary networks

glomus (type I) cells

large, neural crest-derived cells surrounding capillaries around carotid and aortic bodies- filled with dense-core vesicles containing neurotransmitters that regulate blood chemical levels

thoracic duct

lymphatic trunk that enters the cardiovascular system between the left subclavian vein and the left internal jugular vein

right lymphatic duct

lymphatic trunk that enters the cardiovascular system between the right subclavian vein and right internal jugular vein

lymphatic vessels

similar structure to veins except with thinner walls and no distinct separation of tunics and more internal valves, often dilated with lymph, bring lymph back from lymphatic capillaries to lymphatic ducts

lymphatic capillaries

closed-ended vessels with a single layer of endothelial cells on an incomplete basal lamina that collect lymph in tissues

lymph

excess interstitial fluid in tissue spaces that is usually rich in light staining proteins

large veins

big venous trunks with a well-developed intima, thin media with alternating muscle and CT layers, and thick adventitia with longitudinal muscle cell bundles; run with elastic arteries

small and medium veins

veins that correspond to muscular arteries, have diameters of 10mm or less, have a thin subendothelial layer, well-developed adventitia, and a media with muscle cell bundles and reticular and elastic fibers

veins

vessels that carry blood back to heart, have valves to prevent backflow

muscular venules

venules with a tunica media consisting of 2-3 smooth muscle layers, large lumen and thin walls

collecting venules

convergence of postcapillary venules, have more contractile cells than the former

postcapillary venules

structurally similar to capillaries, have pericytes, slightly larger, primary site where white blood cells adhere to endothelium and leave circulation to treat infection/injury

pericytes

mesenchymal cells with long cytoplasmic processes that partly surround the endothelial layer of capillaries and postcapillary venules; make their own basal lamina and have a contractile function

discontinuous capillaries/sinusoids

permit maximal exchange of macromolecules, have endothelial cells with perforations, gaps between cells and a discontinuous basal lamina, have a larger diameter, found in liver, spleen, bone marrow, and some endocrine organs

fenestrated capillaries

sieve-like structure that allows more molecular exchange- endothelial cells have perforations sometimes covered by proteoglycan diaphragms, have a continuous basal lamina, found in kidneys, intestine, choroid plexus, and endocrine glands

continuous capillaries

many tight occluding junctions, slightly overlapping endothelial cells; most common type of capillary; found in muscle, CT, lungs, exocrine glands, and nervous tissue

precapillary sphincters

muscle fibers that contract or relax rhythmically to control entry of blood into capillaries

thoroughfare channels

channels that connect metarterioles to postcapillary venules and bypass capillaries

metarterioles

terminal arteriole branches that supply capillary beds

capillary beds

groups of capillaries around organs, size and structure depends on metabolic activity of organ

capillaries

small vessels that regulate metabolic exchange between blood and surrounding tissues

portal system

system in which a portal vein connects two capillary beds- transport of hormones and nutrients

arteriovenous shunts

a way to bypass capillary networks, media and adventitia thicker

microvasculature

where exchanges between blood and tissue fluid occur

arterioles

smallest artery branches- 1-2 smooth muscle layers, beginning of microvasculature