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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Intended Learning Outcomes
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Describe mechanisms to mobilize Ca2+
Recognize clinical manifestation of -Rickets, osteomalacia -Achondroplasia -Osteitis fibrosa -Osteoporosis -Osteopetrosis -Acromegaly -Osteogenesis imperfecta -Benign tumors of the bone: osteoblastoma, osteoclastoma -Malignant tumors of the bone: osteosarcoma |
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2 types of ossification
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Intramembranous e.g. the flat bones of the skull
Endochondral e.g. all long bones |
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Intramembranous ossification
Location = |
parietal,
frontal, part of occiput, temporal maxillae, mandible clavicle |
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Intramembranous ossification
come from what cells = |
Primitive mesenchymal cells transform directly into osteoblasts.
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Condensation of mesenchyme (starts at
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eighth wk
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Wnt, hedgehog, fibroblast growth factors and transforming growth factor ß group gene products):
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Intramembranous ossification stges =
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.1 Condensation of mesenchyme
2. Development of matrix and differentiation of mesenchymal cells into osteoblasts: |
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Endochondral ossification
3ct |
Condensed mesenchyme model
Transformation Cartilage model Replaced Bone |
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-Condensed mesenchyme model Transformation
- Cartilage model know layers of slide 13 |
ZONES:
-Resting cartlidge (stem cell zone) -Cell proliferation -Cell maturation/hypertrophy cartilage calcification -ossification |
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be able to ID from slide 15 B from PP BONE #3
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.
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Ca++ essential for hardening the newly formed bone
Deficiency = Rickets. The growth plate widens |
Deficiency = Rickets.
info |
The growth plate widens with an increase in soft osteoid and therefore the bones tend to bend.
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. Vit. C.: This is important for the formation of collagen in the matrix of new bone. Deficiency =
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scurvy
info |
The matrix lacks collagen fibers and hemorrhages occur into it so that the growth plate becomes disrupted.
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Achondroplasia
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This is a congenital condition in which the child is born with only poorly formed epiphyseal plates. The trunk and head grow normally but the limbs are short and stunted.
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