Histo:acquired Immunity

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WHAT IS THE UNIQUE ANTIGEN OR A PRIMARY AMINO ACID SEQUENCE SPECIFIC TO AN ANTIBODY

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EPITOPE

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TRUE OR FALSE: EACH CLONE OF B CELLS MAKES ONLY ANTIBODY WITH AN UNIQUE ANTIGEN SPECIFICITY

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TRUE

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NAME THE B CELL RECEPTOR THAT B CELL USES TO BIND ANTIGEN

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TRANSMEMBRANE IgM MOLECULE

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TRUE OR FALSE: B CELL RECEPTOR OF EACH B CELL CLONE HAS ITS UNIQUE ANTIGEN SPECIFICITY.

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TRUE

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A CELL THAT HELPS EXPAND A PARTICULAR CLONE OF B CELL WHEN ITS RECEPTOR BINDS WITH AN ANTIGEN

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T CELL

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DURING EARLY LYMPHOCYTE DEVELOPMENT, WHICH TYPES OF LYMPHOCYTES ARE ELIMINATE

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LYMPHOCYTES WITH RECEPTOR THAT BIND UBIQUITOUS SELF-ANTIGEN

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DURING EARLY LYMPHOCYTE DEVELOPMENT, NAME THE TYPE OF LYMPHOCYTES ALLOW TO MATURE AND RELEASE TO THE PERIPHERAL

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LYMPHOCYTES BEARING RECEPTOR AGAINST FOREIGN ANTIGEN

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STATE THE 4 BASIC PRINCIPLE OF CLONAL SELECTION HYPOTHESIS

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1. A LYMPHOCYTE, W/ A SINGLE TYPE RECEPTOR,W/ A UNIQUE SPECIFICITY
2. INTERACTION OF RECEPTOR TO ITS ANTIGEN LEAD TO PROLIFERATION AND DIFFERENTIATION
3. RECEPTOR ON DAUGHTER CELL MUST BEAR SAME ANTIGEN SPECIFICITY
4. LYMPHOCYTES W/ RECEPTORS AGAINST SELF-MOLECULES ARE DELETED EARLY

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NAME THE PROCESS IMMUNOGLOBULIN GENES UNDERGO DURING B CELL ONTOGENY

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1. SOMATIC DNA RECOMBINANT OR REARRANGEMENT

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1. MAJOR LOCATION WHERE B CELL MATURE 2. TRUE OR FALSE: WE HAVE B CELL REPERTOIRE TOWARD ALL KIND OF ANTIGEN IN THE UNIVERSE

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1. BONE MARROW
2. TRUE

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1. WHAT IS THE NAME FOR HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) 2.NAME A TYPE OF CELL THAT FORM COMPLEX W/ EITHER SELF OR FOREIGN ANTIGENS AND PRESENTED TO T CELL

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1. HLA- HUMAN LEUKOCYTE ANTIGEN
2. MHC- MAJOR HISTOCOMPATIBILITY COPLEX

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NAME THE 2 TYPES OF MHC MOLECULES

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MHC CLASS I
MHC CLASS II

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A TYPE OF MHC MOLECULE THAT COMPLEX W/ CYTOPLASMIC ANTIGEN AND PRESENT TO CYTOTOXIC T CELL

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MHC CLASS I

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A TYPE OF MHC MOLECULE THAT COMPLEX W/ ANTIGEN IN VACUOLES (PHAGOSOMES) AND MOST CASES FORM COMPLEX W/ FOREIGN ANTIGENS

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MHC CLASS II

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ANY CELL THAT BEARS MHC I AND II MOLECULES ARE CALLED
(BROAD DEFINITION)

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ANTIGEN PRESENTING CELL

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WHAT IS DEFINITION OF PROFESSIONAL ANTIGEN PRESENTING CELLS

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CELL IN THE EVIRONMENT, TAKE-UP ANTIGEN, PROCESS IT INTO PEPTIDE AND PRESENT IT TO T CELL COMPLEX W/ MHC II

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NAME THE CELLS THAT ARE CALLED PROFESSIONAL ANTIGEN PRESENTING CELL

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1. MACROPHAGE
2. B CELL
3. DENDRITIC CELL
4. SPECIFIC TYPES OF ENDOTHELIAL CELL
5. HAVE FEATURE OF A REGULAR MHC I BEARING CELLS

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A TYPE OF LYMPHOCYTES CELL INITIATED FROM STEM CELL, MIGRATED TO AND MATURE IN THE THYMUS

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T LYMPHOCYTES

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WHICH LYPHOCYTES CELL DO NOT PRODUCE ANTIBODY? ON IT SURFACE THERE ARE MEMBRANE-BOUND ANTIGEN RECEPTORS SPECIFICALLY BIND TO SPECIFIC ANTIGEN

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T LYMPHOCYTES

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TRUE OR FALSE: ONE CLONE OF T CELL BEARS ONLY ONE KIND OF T CELL RECEPTOR THAT IS SPECIFIC FOR ONE SPECIFIC ANTIGEN.

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TRUE

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WHAT KIND OF ANTIGEN T CELL RECEPTOR ONLY RECOGNIZE

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1. ANTIGEN BOUND TO MHC ON THE SURFACE OF OTHER CELLS
2. T CELLS ONLY RECOGNIZE CELL SURFACE-ASSOCIATED ANTIGEN NOT SOLUBLE ONES

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NAME THE 2 MAJOR CLASSES OF T CELLS

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1. HELPER T CELL
2. CYTOLYTIC (CYTOTOXIC) T CELL

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WHAT ARE THE MEMBRANE- BOUND ANTIGEN RECEPTOR ON T CELL SURFACE CALLED?

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T CELL RECEPTOR: TCR

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NAME THE T CELL THAT BEAR A CO-RECEPTOR (CD4) FOR TCR AND ONLY BIND TO MHC II ANTIGEN COMPLEX

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HELPER T CELL OR CD4+ T CELL

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1. WHAT MOLECULES DO HELPER T CELL SECRETE? 2. NAME THE IMMUNE CELLS THIS MOLECULES ACTIVATE

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1. CYTOKINES
2. B CELLS AND MACROPHAGES

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A T CELL THAT BEAR A CO-RECEPTOR FOR TCR ( CD8 PROTEIN)? CD8-TCR ONLY BINDS TO MHC I ANTIGEN COMPLEX

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CYTOLYTIC T CELL OR CD8+ T CELL

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WHAT TYPE OF CELLS WILL CYTOLYTIC T CELL LYSE

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1. CELL PRESENT W/ FOREIGN ANTIGEN ON IT SURFACE
2. CELL INFECTED W/ VIRUS

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A CELL THAT PHAGOCYTOSED, ENDOCYTOSED AND DIGEST BACTERIAL PATHOGEN? BACTERIAL PEPTIDE IS PRESENTED ON ITS SURFACE IN CONTEXT W/ MHC II, AFTER IT MIGRATE TO A LYMPH NODE VIA LYMPHATIC VESSELS

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ANTIGEN PRESENTING CELL- APC

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A TYPE OF T CELLS LEAVE THE THYMUS AND ENTER BLOOD, CROSSES BLOOD VESSEL WALL OF HIGH ENDOTHELIA VENULES AND FINALLY ENTERS THE INNER CORTEX OF LYMPH NODES

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MATURE BUT NAIVE T CELL

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HOW ARE T CELL ACTIVATED AND START PROLIFERATION?

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INTERACTION OF APC W/ A PARTICULAR ANTIGEN AND T CELL W/ SAME ANTIGEN SPECIFICITY

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A DAUGHTER GENERATION OF T CELL THAT IS READY TO ACTIVATE ANY B CELL AND MACROPHAGE

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ARMED T CELLS

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HOW DOES T CELLS ACTIVATE B CELL TO BEGIN PROLIFERATION AND DIFFERENTIATION INTO ANTIBODY PRODUCING CELL (PLASMA CELL)

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1. B CELL W/ SAME ANTIGEN SPECIFICITY TAKE UP AN ANTIGEN
2. PRESENT THE ANTIGEN PEPTIDE W/ THE MHC II
3. WHEN BOTH (1,2) ENCOUNTER HELPER (CD4+) T CELL W/ SAME ANTIGEN SPECIFICITY

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DESCRIBE HOW CYTOLYTIC (CD8+) T CELL CAN PROLIFERATE

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1. MACROPHAGE PRESENTS VIRAL ANTIGEN IN MHC I TO CYTOLYTIC (CD8+) T CELL (ARMED)

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A TYPE OF CYTOLYTIC T CELL THAT CAN BIND TO VIRAL INFECTED CELL, EX. ENDOTHELIA CELL ,WHOSE MHC I IS COMPLEX W/ FOREIGN ANTIGEN

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CYTOLYTIC T CELL: DAUGHTER GENERATION

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A TYPE OF T CELL THAT RELEASE SUBSTANCES TO KILL INFECTED CELLS TOGETHER W/ VIRUS INSIDE

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CYTOLYTIC (CD8+) T CELL

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A TYPE OF CELL THAT TAKE UP KILLED VIRUS THROUGH ENDOCYTOSIS, PRESENTED IN THE CONTEXT OF MHC II: STIMULATE HELPER T CELL AND ACTIVATE B CELL TO MAKE ANTIBODIES

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ANTIGEN PRESENTING CELLS

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A STEM CELL ALL BLOOD CELLS ARE DERIVED FROM IN THE BONE MARROW

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PLURIPOTENTIAL HEMATOPOIETIC STEM CELL

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A STEM CELL WHICH GIVE RAISE TO LYMPHOCYTES ( BOTH T AND B CELL)

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LYMPHOID MULTIPOTENTIAL CELL

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A STEM CELL WHICH GIVE RAISE TO THE REST OF BLOOD CELL

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MYELOID MULTIPOTENTIAL CELL

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A STAGE OF RBC THAT HAS HIGHLY CONDENSED NUCLEUS AND REFLECT INCREASING AMOUNT OF HEMOGLOBIN IN THE CYTOPLASM

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NORMOBLAST

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A STAGE OF RBC THAT IS THE FIRST STEM CELL INCAPABLE OF MITOSIS AND THE NUCLEUS IS EJECTED

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NORMOBLAST

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A STAGE OF RBC THAT IS LESS MATURE AND CONTAIN RESIDUAL AMOUNT OF RIBOSOMAL RNA

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RETICULOCYTE

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A IMMATURE RBC THAT RETAIN mRNA

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RETICULOCYTES

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THE ORIGIN OF PLATELETS IN THE BONE MARROW

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MEGAKARYOCYTES

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A MAIN SITE OF HEMATOPOIESIS AND DESTRUCTION OF OLD RBC AND STORAGE FOR IRON

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BONE MARROW

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A TYPE OF BONE MARROW PRESENT IN YOUNGER INDIVIDUAL, HEMATOGENOUS

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RED BONE MARROW

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A TYPE OF BONE MARROW IN OLD INDIVIDUAL LOSING BLOOD CELL AND CONTAIN INCREASING # OF ADIPOSE TISSUE

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YELLOW BONE MARROW

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NAME THE STROMA CELL CONTAIN IN BONE MARROW? 3. WHICH IS THE MAJOR MOLECULE

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1. RETICULAR CELL & FIBER
2. COLLAGEN TYPE I AND III
3. COLLAGEN TYPE I AND III

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CELLS THAT MAKE- UP THE HEMATOPOIETIC CORDS

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1. HEMATOPOIETIC CELLS
2. ALL MATURING BLOOD CELL AT DIFFERENT STAGES

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A VESSEL PATH THAT MATURE BLOOD CELLS USE TO MIGRATE FROM BONE MARROW INTO THE CIRCULATION

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SINUSOIDAL CAPILLARIES

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CELLS THAT FORM THE SINUSOIDAL CAPILLARIES OF THE BONE MARROW

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1. CONTINUOUS LAYER OF ENDOTHELIA CELL
2. EXTERNAL DISCONTINUOUS LAYER OF RETICULAR CELL
3. LOOSE NOT OF RETICULAR FIBER