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14 Cards in this Set

  • Front
  • Back
Bone (diff from cart)
Collagen I

Distinct matrix proteins (same as cart)



Contains nerves

bone fxn's
Mechanical support
Reservoir of calcium
epiphysis-bulbous end, (spongy bone covered by compact)

diaphysis-shaft, compact w/ tiny bit of spongy around bone marrow cav.

metaphysis – where diaphysis (shaft) and epiphyseal plate join

epiphyseal plate
articular cartilage – covered epiphysis
periosteum – collagen fiber and fibroblasts

types of bone
Primary-immature, woven

secondary-mature, lamellar bone

compact bone-very dense

Spongy or cancellous bone – porous
components of bone
Cells (osteoblasts, osteocytes, osteoclasts)
Organic material
Inorganic material
Histological preparations
-Ground bone
-Demineralized histological
bone matrix
Organic component
-Collagen I
-Glycoproteins – osteonectin, bone sialoprotein
-Osteoid – non-mineralized organic

Inorganic component
-Mostly calcium and phosphorous in the form of hydroxyapatite crystals
-Also bicarbonate, citrate, magnesium, sodium, potassium
Organization of compact bone
Osteons or Haversian system
Interstitial lamellae
Outer circumferential lamellae
Inner circumferential lamellae
Ground bone
-thin slice of bone
-Lamellae=concentric rings around Haversian Canal
-Lacunae-black spots in lamellae w/ Osteocytes in them
bone vascularization
-Haversian canal-have central blood vessel

-Volkmann's canal-branches off Haversian w/ blood vessels
Bone cells
Osteoprogenitor cells-->osteoblasts

Osteoblasts-CUBOIDAL, basophillic, secrete mat. for mineralization and matrix components from outside of matrix

Bone lining cells-Basophillic, look like fibroblasts, Quiescent Osteoblasts

Osteocytes- Once osteoblasts become surrounded by matrixin, lacunae w/ processes in canaliculi

Osteoclasts-large, multinucleated, acidophilic cell on surface of bone – resorbs bone
Bone formation
Endochondral ossification –(long bone) cartilage = template, replaced with bone

Intramembranous ossification – mainly facial bones; mesenchyme cells condense to form groups, which then make an ossification center

Primary ossification center=diaphysis
secondary ossification center=epiphysis
Endochondrial formation
Resting zones-chondrocytes that aren't proliferating

chondrocytes-die/deposite calcified cart.

Hypertrophic chondrocytes-deposit calcium for bone formation
-Large multi-nub, Acidophillic
-attach to/digest(lysozymes) bone leaving clear space
-pumps calcium and bicarbonate into blood capillaries

-**called chondroclast if digesting calcified cartilage

-Howship's Lacunae-clear space where bone's been resorbed, low pH
Bone Repair
Perosteal proliferation

hyaline cartilage

newly formed primary bone
newly formed secondary bone

healed fracture(secondary bone)