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14 Cards in this Set
- Front
- Back
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Bone (diff from cart)
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Collagen I
Distinct matrix proteins (same as cart) Mineralize Vascularized Contains nerves Dynamic |
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bone fxn's
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Mechanical support
Protection Movement Reservoir of calcium |
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bone-macroscopic
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epiphysis-bulbous end, (spongy bone covered by compact)
diaphysis-shaft, compact w/ tiny bit of spongy around bone marrow cav. metaphysis – where diaphysis (shaft) and epiphyseal plate join epiphyseal plate articular cartilage – covered epiphysis periosteum – collagen fiber and fibroblasts endosteum |
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types of bone
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Primary-immature, woven
secondary-mature, lamellar bone compact bone-very dense Spongy or cancellous bone – porous |
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components of bone
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Cells (osteoblasts, osteocytes, osteoclasts)
Organic material Inorganic material Histological preparations -Ground bone -Demineralized histological preparations |
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bone matrix
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Organic component
-Collagen I -Proteoglycans -Glycoproteins – osteonectin, bone sialoprotein -Osteoid – non-mineralized organic Inorganic component -Mostly calcium and phosphorous in the form of hydroxyapatite crystals -Also bicarbonate, citrate, magnesium, sodium, potassium |
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Organization of compact bone
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Osteons or Haversian system
Interstitial lamellae Outer circumferential lamellae Inner circumferential lamellae |
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Ground bone
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-thin slice of bone
-Lamellae=concentric rings around Haversian Canal -Lacunae-black spots in lamellae w/ Osteocytes in them |
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bone vascularization
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-Haversian canal-have central blood vessel
-Volkmann's canal-branches off Haversian w/ blood vessels |
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Bone cells
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Osteoprogenitor cells-->osteoblasts
Osteoblasts-CUBOIDAL, basophillic, secrete mat. for mineralization and matrix components from outside of matrix Bone lining cells-Basophillic, look like fibroblasts, Quiescent Osteoblasts Osteocytes- Once osteoblasts become surrounded by matrixin, lacunae w/ processes in canaliculi Osteoclasts-large, multinucleated, acidophilic cell on surface of bone – resorbs bone |
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Bone formation
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Endochondral ossification –(long bone) cartilage = template, replaced with bone
Intramembranous ossification – mainly facial bones; mesenchyme cells condense to form groups, which then make an ossification center Primary ossification center=diaphysis secondary ossification center=epiphysis |
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Endochondrial formation
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Resting zones-chondrocytes that aren't proliferating
chondrocytes-die/deposite calcified cart. Hypertrophic chondrocytes-deposit calcium for bone formation |
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Osteoclasts
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-Large multi-nub, Acidophillic
-attach to/digest(lysozymes) bone leaving clear space -pumps calcium and bicarbonate into blood capillaries -**called chondroclast if digesting calcified cartilage -Howship's Lacunae-clear space where bone's been resorbed, low pH |
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Bone Repair
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Perosteal proliferation
hyaline cartilage newly formed primary bone newly formed secondary bone healed fracture(secondary bone) |
