Histo Gi 3

Front 1

Liver stroma contains what types of collagen

Back 1

I and III

Front 2

Describe the flow of blood from the central vein on out

Back 2

Central v., Sublobular v., Hepatic vv., IVC

Front 3

How many portal triads per lobule

Back 3

3 to 6

Front 4

What are the branches of the bile duct found in the portal triad called

Back 4

Canals of Hering

Front 5

Portal triads are located at what part of the classic lobule

Back 5

Corners

Front 6

What pigment can accumulate in hepatocytes

Back 6

Lipofuchin

Front 7

Hepatocytes only begin to divide when

Back 7

If there is injury to the liver

Front 8

Describe the flow of blood and bile in the sinusoid

Back 8

Blood flows from portal triad to central vein. Bile goes the opposite direction, from the middle out to the bile ducts

Front 9

Describe the structure of the Classic lobule

Back 9

Polygonal, Central Vein in the middle, Based on Blood Flow

Front 10

Describe the structure of the Liver Acinus (view of the lobule)

Back 10

Diamond Shaped, 2 cental veins and 2 Portal triads at corners, Center is terminal branches of portal triad, Divided into 3 zones

Front 11

Where is Acinus Zone 1

Back 11

Closest to distributing vessels

Front 12

What are the 1st cells to show changes following bile duct occlusion

Back 12

Zone 1

Front 13

Last cells to die, and 1st to regenerate following circulatory impairment

Back 13

Zone 1

Front 14

Zone that has higher metabolic rate, and is thus more susceptible to toxins

Back 14

Zone 1

Front 15

Zone closest to Central Vein, farthest from blood supply

Back 15

Zone 3

Front 16

First Zone to show Ischemic (Centrilobular) Necrosis

Back 16

Zone 3

Front 17

1st zone to show fatty accumulation

Back 17

Zone 3

Front 18

Last cells to respond to toxins

Back 18

Zone 3

Front 19

Findings in Alcoholic Hepatitis

Back 19

Neutrophils and Necrosis of hepatocytes in Zone 3

Front 20

Zone most susceptible to ischemia/hypoxia

Back 20

Zone 3

Front 21

Heart failure can cause what liver problem

Back 21

Cardiac Cirrhosis (damage to zone 3)

Front 22

Vitamin A is stored in

Back 22

Ito Cells

Front 23

Phagocytes found in liver sinusoids

Back 23

Kupffer Cells

Front 24

Are the liver sinusoids fenestrated? Diaphragms?

Back 24

Fenestrated with NO diaphragms

Front 25

Narrow space between endothelium of sinusoids and hepatocytes

Back 25

Space of Disse

Front 26

Bile canaliculi are formed by

Back 26

walls of hepatocytes

Front 27

Bile ductules are formed by

Back 27

Cuboidal cells (not hepatocytes)

Front 28

Sphincter found in ampulla of Vater

Back 28

Sphincter of Oddi

Front 29

GB releases bile in response to

Back 29

CCK

Front 30

GB mucosa epitheilum type

Back 30

Simple Columnar

Front 31

Type of Submucosa found in GB

Back 31

NONE

Front 32

Deep invaginations of GB mucosa. May indicate early pathologic change

Back 32

Rokitansky-Aschoff Sinuses

Front 33

How is the GB distinguished from the intestine histologically?

Back 33

GB has invaginations of mucosa and no submucosa

Front 34

Brown pigment stones associated with

Back 34

Bacterial Cholangitis (inc UCB)

Front 35

Pancreatic acini formed by

Back 35

Serous cells with spherical nuclei

Front 36

Exocrine pancreas secretions stimulated by

Back 36

CCK or Parasymp. (Vagus)

Front 37

Pancreas cells that produce a bicarb rich secretion

Back 37

Central acinar cells

Front 38

Bicarb rich secretion stimulated by

Back 38

Secretin

Front 39

Secretin secreted by

Back 39

Enteroendocrine cells of duodenum

Front 40

Light staining cells in lumens of acini.

Back 40

Centroacinar cells

Front 41

Centroacinar cells are continuous with

Back 41

initial portion of intercalated duct

Front 42

intercalated duct has what type of epi

Back 42

cuboidal epi

Front 43

interlobular duct cell type

Back 43

columnar cells

Front 44

main/accessory pancreatic duct arises where

Back 44

in the head of the pancreas