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17 Cards in this Set
- Front
- Back
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In the CNS antagonists of H3 autoreceptors and heteroceptors will:
a.Increase release of histamine b.Increase release of non-histamine neurotransmitters c.Increase neuronal firing d.Decrease synthesis of histamine e.All of the above (2006 exam 3) |
e.All of the above
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The sedative effect of the first generation antihistamines was reduced by:
a.Increasing their selectivity for H1 receptors b.Decreasing their lipid solubility and brain penetration c.Combining them with an H2 receptor antagonist d.a and b e.All of the above (2006 exam 3) |
b.Decreasing their lipid solubility and brain penetration
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The following are the main actions of histamine in human EXCEPT:
a. contraction of GI smooth muscle b. increase of blood pressure c. stimulation of gastric secretion d. increased vascular permeability (2004exam3) |
b. increase of blood pressure
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Activation of which presynaptic receptor results in reduction of the release of histamine, 5-HT, norepinephrine or dopamine in CNS:
a. H1 b. H2 c. H3 d. D1 e. none of the above (2004exam3) |
c. H3
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The following are the cells involved in the triple response or the wheal-and-flare response by histamine EXCEPT:
a. epithelial cells b. smooth muscle cells c. sensory nerve cells d. endothelial cells (2004exam3) |
a. epithelial cells
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22. The most common side effect of the first generation H1 antagonists:
a. sedation b. dizziness c. nausea d. dry mouth e. urticaria (2004exam3) |
a. sedation
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Which of the following statements is NOT TRUE about the second generation of H1 antagonists?
a. can inhibit intestinal smooth muscle contraction induced by histamine b. has little or no sedation c. may contraindicate with drugs that inhibit the hepatic P450 enzyme system. d. can inhibit gastric secretion induced by histamine (2004exam3) |
d. can inhibit gastric secretion induced by histamine
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In addition to providing relief of immediate hypersensitivity-type reactions, the first generation histamine H1 antagonists are also useful:
a. as sleep aids b. as antiemetics c. for motion sickness d. a and b e. all of the above (2005 exam 3) |
e. all of the above
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Drug interactions leading to cardiac arrhythmias and in some cases death occurred when second generation antihistaminics (terfenadine and hismanal) were combined with:
a. macrolide antibiotics (e.g., erythromycin) b. antifungal agents (e.g., ketoconazole) c. opiods (e.g., codiene) d. a and b e. all of the above (2005 exam 3) |
d. a and b
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Which of the following drugs should not be given to infants under 2 years of age due to the possibility of respiratory depression?
a. fexofenadine b. promethazine c. brompheniramine d. diphenhydramine e. none of the above should be given to infants (2005 exam 3) |
b. promethazine
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cetirizine is contraindicated in those who are hypersensitive to:
a. hydroxyzine b. desloratidine c. fexofenadine d. a and b e. all of the above (2005 exam 3) |
a. hydroxyzine
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The multiple action of this drug produces somnolence, dries upper respiratory membranes, and is effective in reducing the 'red-wheal flare' response:
a. fexofenadine b. terfenadine c. diphenhydramine d. sumatriptan e. buspirone (2003exam3) |
c. diphenhydramine
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This drug is a second-generation antihistamine no longer marketed in the US:
a. terfenadine b. fexofenadine c. diphenhydramine d. desloratidine e. bromocriptine (2003exam3) |
a. terfenadine
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Non-immunological release of histamine is possible after therapeutic dosing of:
a. morphine b. tubocurarine c. a radio-contrast agent d. a and b e. all of the above (2003exam3) |
e. all of the above
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T/F: cromolyn sodium stabilizes mast cell membranes and thereby reduces symptoms in asthmatic patients
(2003 exam 3) |
true
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T/F: Histamine decreases 'post-capillary venule' permeability; this is H1 or possibly also H3 mediated
(2003 exam 3) |
false
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T/F: histamine decreases appetite
(2003 exam 3) |
true
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