Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
Slowly progressive 'degenerative' arthritis, but low-grade inflammation often a feature
|
Osteoarthritis
|
|
|
Chronic, systemic, inflammatory disease of unknown etiology, progressive joint destruction, loss of physical function, loss of quality of life, increased mortality
|
Rheumatoid Arthritis
|
|
|
Disease modifying anti-reheumatic drugs
|
DMARD's
|
|
|
Minocycline, sulfasalazaine, hydrochloroquine (plaquenil), intramuscular gold (myochrisin), penicillamine (distamine)
|
Older DMARD's
|
|
|
Azathioprine (imuran), cyclophosphamide, cyclosporine (neural, sandimmun)
|
Older immunosuppressant/cytotoxic DMARD's
|
|
|
Exert antirheumatic properties unrelated to antimicrobial effects, side effects include: vestibular toxicity, skin pigmentation, photosenitivity and rarely drug induced lupus
|
Tetracycline derivatives (minocycline)
|
|
|
Powerful metal chelator, also used to treat Wilson's disease, absorbed rapidly, but incompletely from intestine interfered with by food, iron compounds and antacids. Highly protein bound, excreted in kidneys, high toxicityL myositis, drug-induced lupus, rarely used now
|
Penicillamine
|
|
|
More efficacious than auranofin
|
Myochrisine (Both gold compounds)
|
