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13 Cards in this Set
- Front
- Back
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An immunse response to a normally 'innocuous' antigen
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Allergy
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IgE- mediated hypersensitivity, causes hayfever, asthma, anaphylaxis (Allergy)
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Type 1 hypersensitivity
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Releasing histimine
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Degranulation
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Causes vasodilation and increased tissue permeability, can ultimately lead to inflamation, hives, itching, laryngeal edema and wheezing
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Histamine
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Reaction limited to specific tissue or organ (such as allergic rhinitis (hay fever))
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Localised anaphylaxis
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Smooth muscle contraction, systemic vasodilation and massive oedema-blood pressure drops, shock like and fatal state
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Systemic anaphylaxis
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A hereditary predisposition to the development of hypersensitivity reaction against an otherwise innocuous environmental allergen
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Atopy
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Antibody-dependent cell-mediated cytotoxicity
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Type II hypersensitivity
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Immune complex formation hypersensitivity
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Type III hypersensitivity
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Alergy and Asthma; IgE and mast cells hypersensitivity
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Type I hypersensitivity
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Antibody (IgG) coating cells and driving cells death (blood group incompatibility or Rh)
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Type II hypersensitivity
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Immune complex: antibody binds a soluble antigen, forms a complex and drives inflammation
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Type III hypersensitivity
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Bind Fc receptor on mast cell/ basophil, following contact with antigen: release of mediators e.g histamine
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IgE
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