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13 Cards in this Set
- Front
- Back
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Produces antibodies
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B-cells
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CD4+
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Cytokine production (T helper cells)
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CD8+
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Cytotoxic T cells (CTL)
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Occurs after maturation of the B-cells, once migrated to periphery, introduction of mutations in the V regions of rearranged antibody
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Somatic Hypermutation
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Produce cytokines and interact with cells to promote their activation
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Th (T helper cell)
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Activated to kill infected cells
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Tc (Cytotoxic T-cell)
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Only recognise peptide antigen bound to MHC
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T cell receptor
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Multiple germline segments to generate diversity in the TcR
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Combinatorial Diversity
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Addition of non-template encoded (N) and palindromic (P) nucleotides at imprecise joints made between V-D-J elements to generate diversity in the TcR
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Junctional Diversity
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Is somatic mutation used to generate diversity in TcR?
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NO!!!!!!!!!!
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Immature B cells that express high affinity 'self' receptors, these either die, receive antibody editing (mutation) or have long term inactivation
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Negative selection
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Dependent on the stromal cells in the bone marrow
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B cell development
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Thymus provides environment for maturation
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T cell development
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