Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
Mediator of Inflammation: Prostaglandins
|
Pain, vasodilation, fever
|
|
|
Mediator of Inflammation: Nitric oxide
|
vasodilation
|
|
|
Mediator of Inflammation: IL-1
|
Fever
|
|
|
Mediator of Inflammation: Histamine
|
Exudation
|
|
|
Mediator of Inflammation: Bradykinin
|
Exudation, pain, vasodilation
|
|
|
Mediator of Inflammation: C5a
|
chemotaxis
|
|
|
Mediator of Inflammation: IL-8
|
Chemotaxis
|
|
|
Mediator of Inflammation: C3b
|
opsonization --> phagocytosis
|
|
|
T cell ratio
|
CD 4 to CD 8 should be 2:1
In AIDS it's 0.5:1 or less |
|
|
Major histocompatability complex
|
represents an area on chromosome 6
|
|
|
Histocompatibility Genes
|
Genes that code fo HLA represents the genes on the MHC area.
|
|
|
HLA
|
Human Leukocyte antigens, a group of proteins found on certain cells surfaces and represent the protein products of histocompatibility gene expression.
|
|
|
Class I antigens
|
HLA-A -B and C
|
|
|
Class II antigens
|
Includes HLA-DP, DQ, and DR
|
|
|
Nucleated cells
|
All nucleated cells have class I antigens on their cell surface
|
|
|
APCs
|
Antigen presenting cells; includes macrophages, B cells, dendritic cells, All APCs have class II antigens on their cell surface.
|
|
|
IL-3
|
Stimulates bone marrow
|
|
|
TGF alpha
|
stimulates angiogenesis and tumor growth
|
|
|
TGF Beta
|
inhibitis T cells and promotes collagen formation
|
|
|
TNF alpha
|
fever, inhibits lipoproteins lipase, stimulates acute phase response as well as T and B cells
|
|
|
TNF beta
|
similar to alpha
|
|
|
CSF
|
stimualtes bone marroq
|
|
|
RANTES
|
chemotaxis of monoctyes
|
|
|
SRS-A
|
mediates exudation, vasoconstriction, and bronchoconstriction
|
|
|
IL-6
|
fever, stimulates acute phase response
|
|
|
Acute phase response
|
A result of immune system activation, and is induced by IL-1, IL-6, and TNF-alpha. In response to these cytokines, the liver produces acute phase proteins, most notably C-reactive protein, serum amyloid protein, complement proteins, fibrinogen, prothrombin, and other proteins. The clinical features include fever, increased deep sleep, sleepiness during waking hours, decreased appetite, body protein breakdown, and hypotension.
|
