Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
What is potentiation
|
a drug which has no effect enhances the effect of a second drug
|
|
|
|
What other drugs do Aminoglycosides interact with
|
Cephalosporins(inc nephro toxicity), PCN (inactivates some aminoglycosides), Loop diuretics (inc irreversible hearing loss..synergistic)
|
|
|
|
Imidazole antifungals (keto and itraconazole)
|
H2 antagonists and Phenytonin inactivate the antifungals
|
|
|
|
Macrolides (Clindamycin, Erythromycin)
|
anticoagulants (inc activity/hemorrhage), Kaopectate dec absorption of Clinda
|
|
|
|
Metronidazole
|
with EtOH causes Disulfurim rxn (N/V, hypotension, poss coma)
|
|
|
|
Ampicillin
|
with oral anticoagulants, inc anticoagulant activity (like Erythromycin)
|
|
|
|
Drugs that interact with anticoagulants, inc activity
|
Aspirin, Erythromycin, Cephalosporins, H2 antagonists, Phenytonin
|
|
|
|
Drugs that interact with anticoags, dec activity
|
Barbituates, Griseofulvin
|
|
|
|
Insulin reacts with
|
alcohol, beta blockers, MAOI, Salicylates, Steroids (all cause hypoglycemia). Beta blockers blunt the sympa response to hypoglycemia
|
|
|
|
Sulfonylureas (inc insulin release from beta cells) interact with
|
alcohol, anticoagulants, MAOI, NSAIDS…all cause hypoglycemia
|
|
|
|
What happens with sulfonylureas and Thiazide diuretics
|
Hyperglycemia (HCTX dec insulin secretion)
|
|
|
|
What other drug does Indomethacin interact with
|
ACE inhibitors, decreases the hypotensive effect of ACE
|
|
|
|
NSAIDS interact with
|
Anticoagulants (inc bleeding), Beta blockers (impairs anti HTN effects),
|
|
|
|
Which “FOOT” drug can interact with oral contraceptives
|
Griseofulvin
|
|
|
|
What abx can displace uric acid and cause a gouty attack
|
Oxacillin/cloxacilin/dicloxacillin/nafcillin
|
|
|
|
list some drugs that alter Vit K levels (reduce Vit K levels, therfore increase anticoag activity)
|
Abx (PCN, ampicillin, erythromycin, tetracycline)
|
|
|
|
what drugs can cause Hypokalemia (Low K)
|
digoxin, thiazide, furosemide diuretics, corticosteroids
|
Sprionolactone , triamterene, amiloride are K sparing
|
|
|
what effect does thiazide diuretics have on BG levels
|
elevate BG levels
|
|
|
|
name a K sparing diuretic
|
-spironolactone (Aldactone)
|
|
|
|
Neprho/Oto toxic abx
|
Aminoglycosides (gent, tobra, amikacin)
|
|
|
|
rank the following systemic glucocorticoids in order of potentcy (low to high)
Dexametasone, Betamethasone, Cortisol, Triamcinoline, Prednisone |
Cortisol, Prednisone, Triamcinolone, Betamethasone, Dexamethasone
|
|
|
|
Long acting steroid
|
Dexamethasone ACETATE (Decadron -LA), Tramcinolone ACETALOG (Kenalog), Metyhlprednisone ACETATE (Depo-medrol)
|
|
|
|
Short acting steroids
|
Betamethasone soidum phosphate (Celestone), Dexamethasone sodium phosphate (Decadron)
|
|
|
|
MOI of probenecid
|
-inhibits renal absorption of urate, thus increasing its excretion
-a uricosuric agent |
|
|
|
treats acute gout
|
Colchicine
-0.5-1.0 mg per 1-3 hours, max 4 mg per day |
|
|
|
List xanthine osidase inhibitors to tx gout (XO converts X into UA)
|
Allopurinol (contraindicated in an acute attack)
|
|
|
|
centrally acting muscle relaxants
|
-Skelaxin (metazolone)
-Soma (Carisoprodol) -Flexeril (Cyclobenzaprine) -Norflex -Paraflex |
|
