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11 Cards in this Set
- Front
- Back
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Hepatitis A
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- Picornavirus
- + SS RNA - no envelope - enteric transmission - no chronicity |
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Hepatitis B
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- Hepadnavirus
- Partially DS DNA - has an envelope - Parenteral transmission - establishes chronic infection |
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Hepatitis C
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- Flavivirus
- + SS RNA - has an envelope - parenteral transmission - establishes chronic infections |
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transmission of hepatitis viruses
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A - fecal-oral/contaminated food
B - US: sexual, IV drug users; Worldwide, Maternal-fetal C - IV drug users |
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Replication of Hep A
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- produces and cleaves a large polyprotein
- cytoplasmic RNA to RNA replication by a virally encoded polymerase - Released from cells by cytolysis |
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HBsAgs
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- Hep B particles
- Heb B produces 1000x excess of non-infectious subviral particles composed of cellular lipids and viral surface glycoproteins. |
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chronic infection with Hep B
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- 90% neonates
- 5% adults - 40% male chronic carriers die |
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Hepatitis D
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- viroid-like defective virus
- encodes 1 protein, delta antigen - must be concurrent with HBV, provides envelope - RNA to RNA replication by host RNA pol II |
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Hep C features
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- flavivirus similar to yellow fever virus
- uncapped, non-polyadenylated single stranded + polarty RNA - encodes large polyprotein |
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HCV replication
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- viral RNA translated independently of cap to make polyprotein
- replicated in cytoplasm by viral RNA-dependent RNA polymerase - new viruses released w/o killing cell |
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Hep E
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- Non-enveloped, environmentally stable virion
- first member of Hepeviruses - + polarity RNA - single-stranded - 3 ORFs - can cause massive epidemics - highly fatal in pregnancy. |
