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9 Cards in this Set
- Front
- Back
Heparin
class/ MOA |
Class
Anticoagulant. Mechanism of Action Prevents conversion of fibrinogen to fibrin and affect clotting factors: IX, XI, XII, plasmin. Does not lyse existing clots. |
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Heparin
Indications |
Indications
Prophylaxis and treatment of : venous thrombosis, pulmonary embolus, coronary occlusion, disseminated intravascular coagulation (DIC), post-operative thrombosis. To maintain patency of IV injection devices and indwelling catheters. |
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Heparin
Contraindications |
Contraindication
Hypersensitivity. Patients on antiplatelet drugs (relative contraindication) |
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Heparin
Adverse reactions |
Adverse Reactions
Hemorrhage, thrombocytopenia, allergic reactions (chills, fever, back pain). |
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Heparin
Drug Interactions |
Drug Interactions
Salicylates, some antibiotics and quinidine may increase risk of bleeding. |
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Heparin
how supplied |
How Supplied
Heparin lock flush solutions in 10 and 100-unit / ml ampules and prefilled syringes. 1,000 - 40,000 units / ml ampules. |
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Heparin
dose and administration |
Dosage and Administration
Adult: Loading dose: 80 units / kg IV; maintenance dose: 18 units / kg / hour IV. Pediatric: Loading dose: 50 u / kg IV; maintenance dose: 7.5 units / kg / hour IV. |
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Heparin
DOA |
Duration of Action
Onset: Immediate. Peak Effect: Variable. Duration: 4 hours after continuous infusion discontinued |
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Heparin
Specials |
Special Considerations
May be neutralized with protamine sulfate at 1 mg protamine / 100 u Heparin: give slowly IV over 1-3 minutes. |