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5 Cards in this Set
- Front
- Back
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What substances are secreted by activated platelets |
Thromboxane A2 Alpha granules-Fibrinogen and von willebrand factor Delta granules secrete Serotonin, ADP, Calcium |
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List clotting factors and synonyms |
Factor 1 fibrinogen Factor 2 prothrombin 3 tissue factor 4 calcium 5 labile-factor 7 Serum prothrombin conversion accelerator 8 antihemophilic factor A 9 antihemophilic factor B 10 Stuart factor 11 antihemophilic factor C 12 Hageman factor 13 Fibrin-stabilising factor Prekallikerin Platelets Phospholipids |
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Hemorrhagic disease of the newborn |
All newborn infants by about 48 to 72 hours have a transient decrease in vitamin k dependent factors 2,7,910 with a gradual return to normal by the 7th day, but in preterms especially there is sometimes an accentuating and prolonged effect between the 2nd and 7th day of life results in spontaneous and prolonged bleeding Hemorrhagic complications present in breastfed infants |
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What are the differential diagnoses |
Early onset(0-24hours): Inherited coagulopathy Maternal drugs such as Phenytoin and phenobarbital Vitamin k defeciency Classic disease(2-7 days) : Vitamin k defenciency Breastfeeding hemorrhage Late onset(1-6months) Cholestasis-biliary atresia, cystic fibrosis, hepatitis, warfarin ingestion,
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Describe the APT test and what is the principle behind it |
Used to differentiate whether blood passed in the stools in the newborn on the 2nd or 3rd day is due to swallowed blood syndrome or hemorrhagic disease of the newborn, adult hemoglobin reacts with alkaline to change color to yellow brown whiles fetal hemoglobin does not |
