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20 Cards in this Set
- Front
- Back
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Alemtuzumab
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Campath
Binds to CD52 as a tag to attract killer cells |
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Bevacizumab
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Avastin
VEGF antibody Reduces tumor growth by causing existing blood vessels in the tumor to die |
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B
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B1
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C
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C1
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D
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D1
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E
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E1
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Cetuximab
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Erbutix
Chimeric EGFR antibody Prevents the epidermal cell growth factors from binding |
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Gemtuzumab ozogamicin
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Mylotarg
CD33 antibody Endocytosed into the cell, cleaved off, causes DS-DNA breakage |
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Rituximab
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Rituxan
Chimeric Mab against CD20 Binds to CD20 to produce abnormal B-cell development; indirectly causes ADCC=attracts killer cells and CDC=complement activation |
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Trastuzumab
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Herceptin
Humanized Mab Binds to HER-2 receptors to prevent proliferation and angiogenesis of tumor cells |
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Mechlorethamine
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A nitrogen mustard
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Melphalan
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Alkeran
A direct nitrogen mustard alkylator |
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Chlorambucil
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Leukeran
A direct nitrogen mustard alkylator 99% plasma bound, Short t1/2, small % urinary excretion |
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Cyclophosphamide
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Cytoxan
Low plasma binding Longer t1/2 than Chlorambucil Higher % urinary excretion |
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Ifosfamide
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Ifex
Not bound in the plasma Longest t1/2 of nit mustards Highest urinary % excretion |
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Dacarbazine
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DTIC-DOME
Enters cell by passive diffus Adds a methty group to DNA Via diazomethane group to make DNA adduct |
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Busulfan
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Myleran
Direct alkylator A sulfonic acid ester that has 2 sulfonic acids that bind to DNA base and leav most of the molecule to form an adduct |
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Cisplatin
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Platinol-AQ
Extensive tissue distribution >90% protein binding Can persist in tissue for >180 days |
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Antimetabolites
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MOA--interfere with the normal synthesis of nucleic acids and proteins
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Methotrexate
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Folex, Rheumatrex
1 glutamic acid residue works to inhibit thmidylate synthetase which turns dUMP to dTMP and on to DNA |
