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20 Cards in this Set

  • Front
  • Back
Alemtuzumab
Campath
Binds to CD52 as a tag to attract killer cells
Bevacizumab
Avastin
VEGF antibody
Reduces tumor growth by causing existing blood vessels in the tumor to die
B
B1
C
C1
D
D1
E
E1
Cetuximab
Erbutix
Chimeric EGFR antibody
Prevents the epidermal cell growth factors from binding
Gemtuzumab ozogamicin
Mylotarg
CD33 antibody
Endocytosed into the cell, cleaved off, causes DS-DNA breakage
Rituximab
Rituxan
Chimeric Mab against CD20
Binds to CD20 to produce abnormal B-cell development; indirectly causes ADCC=attracts killer cells and CDC=complement activation
Trastuzumab
Herceptin
Humanized Mab
Binds to HER-2 receptors to prevent proliferation and angiogenesis of tumor cells
Mechlorethamine
A nitrogen mustard
Melphalan
Alkeran
A direct nitrogen mustard alkylator
Chlorambucil
Leukeran
A direct nitrogen mustard alkylator
99% plasma bound, Short t1/2, small % urinary excretion
Cyclophosphamide
Cytoxan
Low plasma binding
Longer t1/2 than Chlorambucil
Higher % urinary excretion
Ifosfamide
Ifex
Not bound in the plasma
Longest t1/2 of nit mustards
Highest urinary % excretion
Dacarbazine
DTIC-DOME
Enters cell by passive diffus
Adds a methty group to DNA
Via diazomethane group to make DNA adduct
Busulfan
Myleran
Direct alkylator
A sulfonic acid ester that has 2 sulfonic acids that bind to DNA base and leav most of the molecule to form an adduct
Cisplatin
Platinol-AQ
Extensive tissue distribution
>90% protein binding
Can persist in tissue for >180 days
Antimetabolites
MOA--interfere with the normal synthesis of nucleic acids and proteins
Methotrexate
Folex, Rheumatrex
1 glutamic acid residue
works to inhibit thmidylate synthetase which turns dUMP to dTMP and on to DNA