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19 Cards in this Set
- Front
- Back
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Vincristine
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alkyoid to tubulin - not allow polymerization
Toxicity: neuro (vinblasting - BM) M-phase-specific |
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Tamoxofin
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Also raloxifen
SERM (selective estrogen receptor mediator) Tx: Breast CA, osteoporosis |
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Imatinib
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GLEEVEC
bcr-abl tyrosine kinase inhibitor (oncoprotein for CML) |
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Trastazumab
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HERCEPTIN
HER2 (erb-B2 oncogene) monoclonal antibody against the HER2 estrogen receptor TX: Metastatic Breast CA |
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Paclitax
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(and other taxols)
Bind to tubulin - prevent breakdown M-phase-specific TX: ovarian and breast CA |
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Etoposide
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topoisomerase II inhibitor
G2-phase specific TX: small cell lung CA Toxicity: alopecia, GI |
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Busulfan
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alkylating agent
TX: CML Toxicity: pulmonary fibrosis and hyperpigmentation |
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Cisplatin
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(also carboplatin)
act like aklyating agents TX: urinary, bladder, lung CA Toxicity: nephrotoxicity and acoustic nerve damage |
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Nitrosureas
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alkylate DNA
Cross CNS BBB TX: brain tumors Toxicity: CNS toxicity (dizzy and ataxia) |
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cyclophosphamide
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alkylating agents
TX: non-hodgkins lymphoma Toxicity: myelosupression |
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Doxorubicin
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(adriamyocin)
creates radicals and breaks DNA (intercalates DNA) TX: hodgkins and solit tumors Toxicity: cardio |
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Dactomyocin
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(Actinomycin D)
TX: WT, Ewing Tumor, rhabdomyosarcoma Toxicity: myelosuppresion |
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Cytarabine
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(ara-C)
inhibits DNA Polymerase TX: AML Toxicity: leukopenia, thrombocytopenia, megaloblastic anemia |
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6-mercaptopurine
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6MP
Blocks purine denovo synth TX: NOT CLL or Hodgkins Toxicity: dangerous if w/ allopurinol |
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5-FLuorouracil
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5-FU
thymidylate synthase inhibitor (less dTMP) S-phase specific TX: colon CA and solid tumors Toxicity: irrev myelosuppresion that is NOT reversible with LEUCOVORIN, photosensitivity |
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retinoic acid
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AML type M3 TX
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Methotrexate
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Inihibits DHF reductase (low dTMP)
S-phase dependent TX; everything! (RA, abortions, psoriasisis, leukemias, lymphomas,etc) Toxicity: myelosuppresion that IS reversible w/ leuvorin. macrovesicular change in fatty liver |
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Aciximab
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monoclonal AB against gpIIbIIIa on platelets (prevents agg)
TX in PTCA (percutaneous transluminal coronary angioplasty) |
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Clopidigrel
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(& ticlopidine)
irrev. ADP binding (and prevents future IIbIIIa expression for agg) |
