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19 Cards in this Set

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Vincristine
alkyoid to tubulin - not allow polymerization
Toxicity: neuro (vinblasting - BM)
M-phase-specific
Tamoxofin
Also raloxifen
SERM (selective estrogen receptor mediator)
Tx: Breast CA, osteoporosis
Imatinib
GLEEVEC
bcr-abl tyrosine kinase inhibitor (oncoprotein for CML)
Trastazumab
HERCEPTIN
HER2 (erb-B2 oncogene)
monoclonal antibody against the HER2 estrogen receptor
TX: Metastatic Breast CA
Paclitax
(and other taxols)
Bind to tubulin - prevent breakdown
M-phase-specific
TX: ovarian and breast CA
Etoposide
topoisomerase II inhibitor
G2-phase specific
TX: small cell lung CA
Toxicity: alopecia, GI
Busulfan
alkylating agent
TX: CML
Toxicity: pulmonary fibrosis and hyperpigmentation
Cisplatin
(also carboplatin)
act like aklyating agents
TX: urinary, bladder, lung CA
Toxicity: nephrotoxicity and acoustic nerve damage
Nitrosureas
alkylate DNA
Cross CNS BBB
TX: brain tumors
Toxicity: CNS toxicity (dizzy and ataxia)
cyclophosphamide
alkylating agents
TX: non-hodgkins lymphoma
Toxicity: myelosupression
Doxorubicin
(adriamyocin)
creates radicals and breaks DNA (intercalates DNA)
TX: hodgkins and solit tumors
Toxicity: cardio
Dactomyocin
(Actinomycin D)
TX: WT, Ewing Tumor, rhabdomyosarcoma
Toxicity: myelosuppresion
Cytarabine
(ara-C)
inhibits DNA Polymerase
TX: AML
Toxicity: leukopenia, thrombocytopenia, megaloblastic anemia
6-mercaptopurine
6MP
Blocks purine denovo synth
TX: NOT CLL or Hodgkins
Toxicity: dangerous if w/ allopurinol
5-FLuorouracil
5-FU
thymidylate synthase inhibitor (less dTMP)
S-phase specific
TX: colon CA and solid tumors
Toxicity: irrev myelosuppresion that is NOT reversible with LEUCOVORIN, photosensitivity
retinoic acid
AML type M3 TX
Methotrexate
Inihibits DHF reductase (low dTMP)
S-phase dependent
TX; everything! (RA, abortions, psoriasisis, leukemias, lymphomas,etc)
Toxicity: myelosuppresion that IS reversible w/ leuvorin.
macrovesicular change in fatty liver
Aciximab
monoclonal AB against gpIIbIIIa on platelets (prevents agg)
TX in PTCA (percutaneous transluminal coronary angioplasty)
Clopidigrel
(& ticlopidine)
irrev. ADP binding (and prevents future IIbIIIa expression for agg)