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40 Cards in this Set
- Front
- Back
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JAK2 mutation
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Mutation in PV, ET, MMM
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t(15;17)
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Translocation in M3/promyelocytic AML
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t(9;22)
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Translocation in CML
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CD10+ (CALLA+), tDt+
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B-ALL marker
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CD20dim+, CD23+, CD5+, CD19+
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CLL marker
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CD103+, CD25+ CD11c+
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Hairy Cell Leukemia marker
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Stains TRAP+
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Hair Cell Leukemia stain
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CD4+, tDt-
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Adult T-Cell Leukemia/Lymphoma marker
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CD10+, tDt+, CD24+ CD19+, CD79+
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B-lymphoblastic L/L (immature) marker
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CD3+, CD5+, tDT+
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T-Lymphoblastic L/L (immature) markers
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CD10+, CD20+, CD5-, CD3-
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Follicular Lymphoma marker
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BCL2 overexpression
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Follicular Lymphoma over expresses this
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t(14,18)
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Translocation in Follicular Lymphoma
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CD20bright+, CD5+, CD23-, cyclinD1+, lambda+
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Mantle Cell Lymphoma marker
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t(11,14)
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Translocation in Mantle Cell Lymphoma
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t(8;14), c-myc oncogene
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Translocation in Burkitt's Lymphoma
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Ki-67 = 100%
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Burkitt's Lymphoma expresses this
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CD3+, CD7-, CD26-, CD4+
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Mycosis Fungoides (sezary syndrome) marker
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CD15+, CD30+, CD45-
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Hodgkins Lymphoma marker (classical)
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CD15-, CD30-, CD45+
CD20+, CD57+ |
Nodular Lymphocyte Predominant HL (NLPHL)
(aka "NON-CLASSICAL" HL) |
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S100+, CD1a+, CD207
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Langerhans Cell Histiocytosis marker
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tennis racket shaped (birbeck granules)
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Langerhans Cell Histiocytosis marker
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Signs of GOOD prognosis in AML
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t(8;21)inv(16)
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Signs of GOOD prognosis in ALL
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t(12;21)= TEL-AML1
1-10yo WBC<50,000 hyperdiploidy |
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Signs of POOR prognosis in ALL
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philadelphia chromosome
MLL/11q23 hypodiploidy |
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Signs of POOR prognosis in CLL
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zap70 (pre-GC, unmutated Ig)
CD38+ Trisomy 12 |
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Age Group: ALL
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0-14yo
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Age Group: AML
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15-60yo
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Age Group: CML
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40-60+ yo
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Age Group: CLL
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>60yo
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7 factors of the Hodgkin Disease International Prognostic Score
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Age>45; Male; Stage 4;
alb<4; Hb<10.5; WBC>15k; lymphopenia |
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Variant of HL with:
many lymphocytes & few RS |
Lymphocyte predominant HL
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Variant of HL with:
fibrous bands, lacunar cells, F>M |
Nodular Sclerosis HL
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Variant of HL with:
eosinophils, plasma cells, fibrosis, setting of HIV, EBV-assoc, lower SES |
Mixed Cellularity HL
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Variant of HL with:
few lymphocytes, many RS cells, necrosis, aggressive w/ B-Sx |
Lymphocyte-Depletion HL
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Variant of HL with:
noB-Sx, no RS, peripher LAD, L&H "popcorn" cells; good prognosis |
Nodular Lymphocyte Predeominant HL (NLPHL)
aka: "non-classical HL" |
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DiGeorge Syndrome defect
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chrom 22q11.2
Failure of 3rd and 4th pharyngeal pouches to develop (no thymic envelope) T-B+ |
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Wiskott Aldrich syndrome Triad
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eczema
thrombocytopenia immunodeficiency syndrome (SP infxns) |
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Hand-Schuller Christian Sx
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Diabetes Insipidus
Skull lesions exophthalmos |
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Letterer-Siwe Dz Sx
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LAD, Skin lesions, Diarrhea
pancytopenia, failure to thrive, osteolytic bone lesions, pulmonary lesions |
