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15 Cards in this Set
- Front
- Back
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Pb poisoning
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denatures enzymes: ribonuclease, ALA dehydrogenase, ferrochetalase
bone deposits, GI, neuro, renal, sideroblastic anemia, fanconi's syndrome |
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fanconi's syndrome vs. Kaposi's syndrome
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fanconi's: proximal renal tubular acidosis; AA, phosphate, glucose in urine
Kaposi's: assoc w/ HIV |
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homocysteinuria
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folate and B12 deficiency
methyl-B12 converts HC to methionine |
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extravascular hemolysis
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macrophage phagocytosis, unconj hyperbilirubinemia
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intravascular hemolysis
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dec haptoglobin, hemoglobinuria
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hereditary spherocytosis
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(normocytic anemia w/ correction) osmotic fragility
intrinsic defect, extravascular hemolysis; mutation in ankyrin in cell membrane and spectrin --> dysfxn in Na-K-ATPase pump parvovirus --> aplastic crisis |
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paroxysmal nocturnal hemoglobinuria
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(normocytic) pancytopenia
acquired membrane defect, loss of anchor for DAF, intravascular hemolysis -screen with sucrose hemolysis test --> enhances complement destruction of RBCs |
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heinz bodies and bite cells
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G6PD
intravascular hemolysis; oxidant damage |
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pyruvate kinase deficiency
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normocytic anemia
loss of ATP --> membrane damage --> dehydration of RBC (echinocytes -- thorny RBCs) increase 2,3 BPG --> asymptomatic |
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autoimmune hemolytic anemia
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extravascular hemolysis -->UCB --> jaundice
warm: IgG -- +/- C3b, SLE, DAT cold: IgM -- w/ C3b, IAMHE; intra/extravascular |
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plasmodium vivax
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common
tertian fever pattern |
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plasmodium falciparum
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lethal
quotidian fever pattern (daily spikes) |
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plasmodium malariae
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nephrotic syndrome
quartan fever pattern |
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G6PD
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x-recessive
dec glutathione --> ox damage to membrane and Hb; intravascular; heinz bodis and bite cells |
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corticosteroids affects on WBCs
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neutrophilic leukocytosis, eosinopenia, lymphopenia
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